TY - JOUR
T1 - Hormonal contraception and HIV acquisition
T2 - Reanalysis using marginal structural modeling
AU - Morrison, Charles S.
AU - Chen, Pai Lien
AU - Kwok, Cynthia
AU - Richardson, Barbra A.
AU - Chipato, Tsungai
AU - Mugerwa, Roy
AU - Byamugisha, Josaphat
AU - Padian, Nancy
AU - Celentano, David D.
AU - Salata, Robert A.
PY - 2010/7/17
Y1 - 2010/7/17
N2 - Hormonal contraceptives are used widely worldwide; their effect on HIV acquisition remains unresolved. We reanalyzed data from the Hormonal Contraception and HIV Study using marginal structural modeling to reduce selection bias due to time-dependent confounding. Replicating our original analysis closely, we found that depo-medroxyprogesterone acetate (DMPA) but not combined oral contraceptive (COC) was associated with increased HIV acquisition. Also, young (18-24 years) but not older women who used DMPA and COCs were at increased HIV risk.
AB - Hormonal contraceptives are used widely worldwide; their effect on HIV acquisition remains unresolved. We reanalyzed data from the Hormonal Contraception and HIV Study using marginal structural modeling to reduce selection bias due to time-dependent confounding. Replicating our original analysis closely, we found that depo-medroxyprogesterone acetate (DMPA) but not combined oral contraceptive (COC) was associated with increased HIV acquisition. Also, young (18-24 years) but not older women who used DMPA and COCs were at increased HIV risk.
UR - http://www.scopus.com/inward/record.url?scp=77954335439&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954335439&partnerID=8YFLogxK
U2 - 10.1097/QAD.0b013e32833a2537
DO - 10.1097/QAD.0b013e32833a2537
M3 - Article
C2 - 20588106
AN - SCOPUS:77954335439
SN - 0269-9370
VL - 24
SP - 1778
EP - 1781
JO - AIDS
JF - AIDS
IS - 11
ER -