Horizontal gene transfer is not a hallmark of the human genome

Steven L. Salzberg

doi:10.1186/s13059-017-1214-2

Horizontal gene transfer is not a hallmark of the human genome

Steven L. Salzberg

School of Medicine

Research output: Contribution to journal › Letter › peer-review

25 Scopus citations

Abstract

Crisp et al. recently reported that 145 human genes have been horizontally transferred from distant species. Here, I re-analyze those genes listed by Crisp et al. as having the highest certainty of having been horizontally transferred, as well as 17 further genes from the 2001 human genome article, and find little or no evidence to support claims of horizontal gene transfer (HGT). Please see related Research article: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0607-3.

Original language	English (US)
Article number	85
Journal	Genome biology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s13059-017-1214-2
State	Published - May 8 2017

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Genetics
Cell Biology

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title = "Horizontal gene transfer is not a hallmark of the human genome",

abstract = "Crisp et al. recently reported that 145 human genes have been horizontally transferred from distant species. Here, I re-analyze those genes listed by Crisp et al. as having the highest certainty of having been horizontally transferred, as well as 17 further genes from the 2001 human genome article, and find little or no evidence to support claims of horizontal gene transfer (HGT). Please see related Research article: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0607-3.",

author = "Salzberg, {Steven L.}",

note = "Funding Information: This work was supported in part by the US National Institutes of Health under grants R01-GM083873 and R01-HG006677. Publisher Copyright: {\textcopyright} 2017 The Author(s).",

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AB - Crisp et al. recently reported that 145 human genes have been horizontally transferred from distant species. Here, I re-analyze those genes listed by Crisp et al. as having the highest certainty of having been horizontally transferred, as well as 17 further genes from the 2001 human genome article, and find little or no evidence to support claims of horizontal gene transfer (HGT). Please see related Research article: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0607-3.

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Horizontal gene transfer is not a hallmark of the human genome

Abstract

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