TY - JOUR
T1 - Homozygous factor-V mutation as a genetic cause of perinatal thrombosis and cerebral palsy
AU - Harum, Karen H.
AU - Hoon, Alec
AU - Kato, Gregory
AU - Casella, James F.
AU - Breiter, Steven N.
AU - Johnston, Michael V
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999
Y1 - 1999
N2 - A 5-year old girl with cerebral palsy (CP), preterm birth, postnatal aortic thrombus, and cerebellar venous infarction who is homozygous for the thrombophilic factor-V Leiden (fVL) mutation is reported. The role of hereditary thrombophilic disorders in the development of perinatal vascular lesions such as aortic thrombi, renal-vein thrombosis, venous-sinus thrombosis, and cerebral infarction is unknown. This case report brings into question a potential association between fVL, perinatal vascular lesions, perinatal stroke, and CP.
AB - A 5-year old girl with cerebral palsy (CP), preterm birth, postnatal aortic thrombus, and cerebellar venous infarction who is homozygous for the thrombophilic factor-V Leiden (fVL) mutation is reported. The role of hereditary thrombophilic disorders in the development of perinatal vascular lesions such as aortic thrombi, renal-vein thrombosis, venous-sinus thrombosis, and cerebral infarction is unknown. This case report brings into question a potential association between fVL, perinatal vascular lesions, perinatal stroke, and CP.
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U2 - 10.1017/S0012162299001541
DO - 10.1017/S0012162299001541
M3 - Article
C2 - 10576642
AN - SCOPUS:0032711382
SN - 0012-1622
VL - 41
SP - 777
EP - 780
JO - Developmental medicine and child neurology
JF - Developmental medicine and child neurology
IS - 11
ER -