A simple pulse scheme is given for obtaining echoes with both chemical shift and homonuclear scalar coupling refocused. The procedure is illustrated for some biologically important nuclei, namely 31P in ATP and 1H in lactate. The refocusing of the scalar coupling J is perfect for AX systems, but incomplete for multiply coupled spins. However, for the latter, a gain in in-phase intensity is still obtained at relatively long echo times (<3/4J). Theory, in terms of the operator formalism, and experiment are presented for AXn systems and are in good agreement. Strategies to remove spectral artifacts resulting from pulse angle deviations are given.