Homology Modeling of the Transmembrane Domain of the Human Calcium Sensing Receptor and Localization of an Allosteric Binding Site

Medicine & Life Sciences

• N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine 100%
• Allosteric Site 75%
• Calcium-Sensing Receptors 70%
• N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine 64%
• Rhodopsin 45%
• Binding Sites 41%
• Mutation 29%
• Cattle 28%
• Phenylalanine 19%
• Hydroxyl Radical 19%
• Automobiles 19%
• G-Protein-Coupled Receptors 17%
• Mutagenesis 17%

Chemical Compounds

• Mutation 45%
• Calcium(0) 40%
• Binding Site 37%
• Calcimimetic 34%
• Antagonist 33%
• Phenylalanine 17%
• Agonist 17%