Homologous N-alkylnorketobemidones. Correlation of receptor binding with analgesic potency

Raymond S. Wilson, Michael E. Rogers, Candace B. Pert, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

For a homologous series of N-alkylnorketobemidones a statistically significant correlation was found between the relative abilities to bind mouse brain homogenate in vitro and their in vivo mouse hot-plate analgesic potencies. The correlation between in vitro binding in the presence of 100 mM sodium and analgesic potency was not as good as that found in the absence of sodium. A statistically significant correlation was also found between their analgesic potencies and their abilities to antagonize electrically induced contractions of the guinea pig ileum.

Original languageEnglish (US)
Pages (from-to)240-242
Number of pages3
JournalJournal of Medicinal Chemistry
Volume18
Issue number3
StatePublished - 1975

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Analgesics
Sodium
Ileum
Brain
Guinea Pigs
In Vitro Techniques

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Homologous N-alkylnorketobemidones. Correlation of receptor binding with analgesic potency. / Wilson, Raymond S.; Rogers, Michael E.; Pert, Candace B.; Snyder, Solomon H.

In: Journal of Medicinal Chemistry, Vol. 18, No. 3, 1975, p. 240-242.

Research output: Contribution to journalArticle

Wilson, Raymond S. ; Rogers, Michael E. ; Pert, Candace B. ; Snyder, Solomon H. / Homologous N-alkylnorketobemidones. Correlation of receptor binding with analgesic potency. In: Journal of Medicinal Chemistry. 1975 ; Vol. 18, No. 3. pp. 240-242.
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