Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development

Lisa D. Wiggins, Lin H. Tian, Susan E. Levy, Catherine Rice, Li Ching Lee, Laura Schieve, Juhi Pandey, Julie Daniels, Lisa Blaskey, Susan Hepburn, Rebecca Landa, Rebecca Edmondson-Pretzel, William Thompson

Research output: Contribution to journalArticle

Abstract

The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalJournal of Autism and Developmental Disorders
DOIs
StateAccepted/In press - Sep 6 2017

Fingerprint

Autistic Disorder
Pervasive Child Development Disorders
Language Development Disorders

Keywords

  • Autism
  • Autism spectrum disorder
  • Characterization
  • Phenotypes
  • Subgroups

ASJC Scopus subject areas

  • Developmental and Educational Psychology

Cite this

Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development. / Wiggins, Lisa D.; Tian, Lin H.; Levy, Susan E.; Rice, Catherine; Lee, Li Ching; Schieve, Laura; Pandey, Juhi; Daniels, Julie; Blaskey, Lisa; Hepburn, Susan; Landa, Rebecca; Edmondson-Pretzel, Rebecca; Thompson, William.

In: Journal of Autism and Developmental Disorders, 06.09.2017, p. 1-12.

Research output: Contribution to journalArticle

Wiggins, LD, Tian, LH, Levy, SE, Rice, C, Lee, LC, Schieve, L, Pandey, J, Daniels, J, Blaskey, L, Hepburn, S, Landa, R, Edmondson-Pretzel, R & Thompson, W 2017, 'Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development' Journal of Autism and Developmental Disorders, pp. 1-12. DOI: 10.1007/s10803-017-3280-4

Wiggins, Lisa D.; Tian, Lin H.; Levy, Susan E.; Rice, Catherine; Lee, Li Ching; Schieve, Laura; Pandey, Juhi; Daniels, Julie; Blaskey, Lisa; Hepburn, Susan; Landa, Rebecca; Edmondson-Pretzel, Rebecca; Thompson, William / Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development.

In: Journal of Autism and Developmental Disorders, 06.09.2017, p. 1-12.

Research output: Contribution to journalArticle

@article{be2c1b979e784ad7a1f14460e486569c,
title = "Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development",
abstract = "The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed.",
keywords = "Autism, Autism spectrum disorder, Characterization, Phenotypes, Subgroups",
author = "Wiggins, {Lisa D.} and Tian, {Lin H.} and Levy, {Susan E.} and Catherine Rice and Lee, {Li Ching} and Laura Schieve and Juhi Pandey and Julie Daniels and Lisa Blaskey and Susan Hepburn and Rebecca Landa and Rebecca Edmondson-Pretzel and William Thompson",
year = "2017",
month = "9",
doi = "10.1007/s10803-017-3280-4",
pages = "1--12",
journal = "Journal of Autism and Developmental Disorders",
issn = "0162-3257",
publisher = "Springer New York",

}

TY - JOUR

T1 - Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development

AU - Wiggins,Lisa D.

AU - Tian,Lin H.

AU - Levy,Susan E.

AU - Rice,Catherine

AU - Lee,Li Ching

AU - Schieve,Laura

AU - Pandey,Juhi

AU - Daniels,Julie

AU - Blaskey,Lisa

AU - Hepburn,Susan

AU - Landa,Rebecca

AU - Edmondson-Pretzel,Rebecca

AU - Thompson,William

PY - 2017/9/6

Y1 - 2017/9/6

N2 - The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed.

AB - The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed.

KW - Autism

KW - Autism spectrum disorder

KW - Characterization

KW - Phenotypes

KW - Subgroups

UR - http://www.scopus.com/inward/record.url?scp=85028853603&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028853603&partnerID=8YFLogxK

U2 - 10.1007/s10803-017-3280-4

DO - 10.1007/s10803-017-3280-4

M3 - Article

SP - 1

EP - 12

JO - Journal of Autism and Developmental Disorders

T2 - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

SN - 0162-3257

ER -