Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of Homer-related, synaptic proteins

Bo Xiao, Jian Cheng Tu, Ronald S. Petralia, Joseph P. Yuan, Andrew Doan, Christopher D. Breder, Alicia Ruggiero, Anthony A. Lanahan, Robert J. Wenthold, Paul F. Worley

Research output: Contribution to journalArticlepeer-review

514 Scopus citations

Abstract

Homer is a neuronal immediate early gene (IEG) that is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs). Here, we characterize a family of Homer-related proteins derived from three distinct genes. Like Homer IEG (now termed Homer la), all new members bind group 1 mGluRs. In contrast to Homer 1a, new members are constitutively expressed and encode a C-terminal coiled-coil (CC) domain that mediates self-multimerization. CC-Homers form natural complexes that cross- link mGluRs and are enriched at the postsynaptic density. Homer 1a does not multimerize and blocks the association of mGluRs with CC-Homer complexes. These observations support a model in which the dynamic expression of Homer la competes with constitutively expressed CC-Homers to modify synaptic mGluR properties.

Original languageEnglish (US)
Pages (from-to)707-716
Number of pages10
JournalNeuron
Volume21
Issue number4
DOIs
StatePublished - Oct 1998

ASJC Scopus subject areas

  • General Neuroscience

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