TY - JOUR
T1 - Homer proteins
T2 - implications for neuropsychiatric disorders
AU - Szumlinski, Karen K.
AU - Kalivas, Peter W.
AU - Worley, Paul F.
N1 - Funding Information:
This work was supported by United States Public Health Service grants DA-11742 and DA-10307 to PF Worley, DA-03906, DA-14185, MH-40817 and P50-AA1076 (Project #2) to PW Kalivas, in addition to P50-AA1076 (pilot project) and AA-013519 (pilot project, Integrative Neuroscience Initiative on Alcoholism West) to KK Szumlinski. This work was also supported by funding from the National Alliance for Research on Schizophrenia and Affective Disorders (NARSAD) to KK Szumlinski.
PY - 2006/6
Y1 - 2006/6
N2 - Homer proteins regulate signal transduction, synaptogenesis and receptor trafficking, in addition to maintaining and regulating extracellular glutamate levels in limbo-corticostriatal brain regions. Converging preclinical observations indicate a potential role for both immediate early gene Homer isoforms and constitutively expressed Homer isoforms in behavioral pathologies associated with neuropsychiatric disorders, such as addiction and/or alcoholism, depression, anxiety, epilepsy and schizophrenia.
AB - Homer proteins regulate signal transduction, synaptogenesis and receptor trafficking, in addition to maintaining and regulating extracellular glutamate levels in limbo-corticostriatal brain regions. Converging preclinical observations indicate a potential role for both immediate early gene Homer isoforms and constitutively expressed Homer isoforms in behavioral pathologies associated with neuropsychiatric disorders, such as addiction and/or alcoholism, depression, anxiety, epilepsy and schizophrenia.
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U2 - 10.1016/j.conb.2006.05.002
DO - 10.1016/j.conb.2006.05.002
M3 - Review article
C2 - 16704932
AN - SCOPUS:33745220274
VL - 16
SP - 251
EP - 257
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
SN - 0959-4388
IS - 3
ER -