Homer proteins: implications for neuropsychiatric disorders

Karen K. Szumlinski, Peter W. Kalivas, Paul F. Worley

Research output: Contribution to journalReview articlepeer-review

Abstract

Homer proteins regulate signal transduction, synaptogenesis and receptor trafficking, in addition to maintaining and regulating extracellular glutamate levels in limbo-corticostriatal brain regions. Converging preclinical observations indicate a potential role for both immediate early gene Homer isoforms and constitutively expressed Homer isoforms in behavioral pathologies associated with neuropsychiatric disorders, such as addiction and/or alcoholism, depression, anxiety, epilepsy and schizophrenia.

Original languageEnglish (US)
Pages (from-to)251-257
Number of pages7
JournalCurrent Opinion in Neurobiology
Volume16
Issue number3
DOIs
StatePublished - Jun 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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