Homer binds a novel proline-rich motif and links group I metabotropic glutamate receptors with IP3 receptors

Jian Cheng Tu, Bo Xiao, Joseph P. Yuan, Anthony A. Lanahan, Kathleen Leoffert, Min Li, David J. Linden, Paul F. Worley

Research output: Contribution to journalArticle

Abstract

Group 1 metabotropic glutamate receptors (mGluRs) activate PI turnover and thereby trigger intracellular calcium release. Previously, we demonstrated that mGluRs form natural complexes with members of a family of Homer-related synaptic proteins. Here, we present evidence that Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R). A novel proline-rich 'Homer ligand' (PPXXFr) is identified in group 1 mGluRs and IP3R, and these receptors coimmunoprecipitate as a complex with Homer from brain. Expression of the lEG form of Homer, which lacks the ability to cross-link, modulates mGluR- induced intracellular calcium release. These studies identify a novel mechanism in calcium signaling and provide evidence that an lEG, whose expression is driven by synaptic activity, can directly modify a specific synaptic function.

Original languageEnglish (US)
Pages (from-to)717-726
Number of pages10
JournalNeuron
Volume21
Issue number4
DOIs
StatePublished - Oct 1998

ASJC Scopus subject areas

  • Neuroscience(all)

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