Homer: A link between neural activity and glutamate receptor function

Bo Xiao; Jian Cheng Tu; Paul F. Worley

doi:10.1016/S0959-4388(00)00087-8

Homer: A link between neural activity and glutamate receptor function

Bo Xiao, Jian Cheng Tu, Paul F. Worley

School of Medicine

Research output: Contribution to journal › Review article › peer-review

350 Scopus citations

Abstract

The proteins of the Homer family bind to proline-rich sequences in group I metabotropic glutamate receptors, inositol trisphosphate receptors, ryanodine receptors, and Shank family proteins. Homer proteins also self associate and function as adaptors to couple interacting proteins. Recent observations indicate a role for Homer complexes in signal transduction, synaptogenesis and receptor trafficking.

Original language	English (US)
Pages (from-to)	370-374
Number of pages	5
Journal	Current Opinion in Neurobiology
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/S0959-4388(00)00087-8
State	Published - Jun 1 2000

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0959-4388(00)00087-8

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title = "Homer: A link between neural activity and glutamate receptor function",

abstract = "The proteins of the Homer family bind to proline-rich sequences in group I metabotropic glutamate receptors, inositol trisphosphate receptors, ryanodine receptors, and Shank family proteins. Homer proteins also self associate and function as adaptors to couple interacting proteins. Recent observations indicate a role for Homer complexes in signal transduction, synaptogenesis and receptor trafficking.",

author = "Bo Xiao and {Cheng Tu}, Jian and Worley, {Paul F.}",

note = "Funding Information: We thank our collaborators who have contributed much to the understanding of Homer. We also thank Jutta Benneken for preparation of Figure 2 . This work was supported by grants from National Institute on Drug Abuse (NIDA), National Institute of Mental Health (NIMH) and National Alliance for Research on Schizophrenia and Depression (NARSAD). ",

year = "2000",

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doi = "10.1016/S0959-4388(00)00087-8",

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T1 - Homer

T2 - A link between neural activity and glutamate receptor function

AU - Xiao, Bo

AU - Cheng Tu, Jian

AU - Worley, Paul F.

N1 - Funding Information: We thank our collaborators who have contributed much to the understanding of Homer. We also thank Jutta Benneken for preparation of Figure 2 . This work was supported by grants from National Institute on Drug Abuse (NIDA), National Institute of Mental Health (NIMH) and National Alliance for Research on Schizophrenia and Depression (NARSAD).

PY - 2000/6/1

Y1 - 2000/6/1

N2 - The proteins of the Homer family bind to proline-rich sequences in group I metabotropic glutamate receptors, inositol trisphosphate receptors, ryanodine receptors, and Shank family proteins. Homer proteins also self associate and function as adaptors to couple interacting proteins. Recent observations indicate a role for Homer complexes in signal transduction, synaptogenesis and receptor trafficking.

AB - The proteins of the Homer family bind to proline-rich sequences in group I metabotropic glutamate receptors, inositol trisphosphate receptors, ryanodine receptors, and Shank family proteins. Homer proteins also self associate and function as adaptors to couple interacting proteins. Recent observations indicate a role for Homer complexes in signal transduction, synaptogenesis and receptor trafficking.

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U2 - 10.1016/S0959-4388(00)00087-8

DO - 10.1016/S0959-4388(00)00087-8

M3 - Review article

C2 - 10851183

AN - SCOPUS:0342313718

SN - 0959-4388

VL - 10

SP - 370

EP - 374

JO - Current Opinion in Neurobiology

JF - Current Opinion in Neurobiology

IS - 3

ER -

Homer: A link between neural activity and glutamate receptor function

Abstract

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