Homeostatic Scaling Requires Group I mGluR Activation Mediated by Homer1a

Jia Hua Hu, Joo Min Park, Sungjin Park, Bo Xiao, Marlin H. Dehoff, Sangmok Kim, Takashi Hayashi, Martin K. Schwarz, Richard L. Huganir, Peter H. Seeburg, David J. Linden, Paul F. Worley

Research output: Contribution to journalArticlepeer-review

156 Scopus citations


Homeostatic scaling is a non-Hebbian form of neural plasticity that maintains neuronal excitability and informational content of synaptic arrays in the face of changes of network activity. Here, we demonstrate that homeostatic scaling is dependent on group I metabotropic glutamate receptor activation that is mediated by the immediate early gene Homer1a. Homer1a is transiently upregulated during increases in network activity and evokes agonist-independent signaling of group I mGluRs that scales down the expression of synaptic AMPA receptors. Homer1a effects are dynamic and play a role in the induction of scaling. Similar to mGluR-LTD, Homer1a-dependent scaling involves a reduction of tyrosine phosphorylation of GluA2 (GluR2), but is distinct in that it exploits a unique signaling property of group I mGluR to confer cell-wide, agonist-independent activation of the receptor. These studies reveal an elegant interplay of mechanisms that underlie Hebbian and non-Hebbian plasticity.

Original languageEnglish (US)
Pages (from-to)1128-1142
Number of pages15
Issue number6
StatePublished - Dec 22 2010

ASJC Scopus subject areas

  • Neuroscience(all)


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