Homeostatic regulation of AMPA receptor expression at single hippocampal synapses

Qingming Hou, Dawei Zhang, Larissa Jarzylo, Richard L. Huganir, Heng Ye Man

Research output: Contribution to journalArticlepeer-review

114 Scopus citations


Homeostatic synaptic response is an important measure in confining neuronal activity within a narrow physiological range. Whether or not homeostatic plasticity demonstrates synapse specificity, a key feature characteristic of Hebbian-type plasticity, is largely unknown. Here, we report that in cultured hippocampal neurons, α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid subtype glutamate receptor (AMPAR) accumulation is increased selectively in chronically inhibited single synapses, whereas the neighboring normal synapses remain unaffected. This synapse-specific homeostatic regulation depends on the disparity of synaptic activity and is mediated by GluR2-lacking AMPARs and PI3-kinase signaling. These results demonstrate the existence of synaptic specificity and the crucial role of AMPAR-gated calcium in homeostatic plasticity in central neurons.

Original languageEnglish (US)
Pages (from-to)775-780
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number2
StatePublished - Jan 15 2008


  • Kir 2.1
  • Single synapse
  • Synaptic plasticity
  • Synaptic specificity

ASJC Scopus subject areas

  • General


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