Homeodomain interactions

Research output: Contribution to journalArticle

Abstract

Homeodomain proteins play key roles in development and gene regulation in eukaryotes. Past structural studies have focused on the binding of monomeric homeodomains to DNA, but two recent structures have revealed how homeodomains bind DNA as multimers. The structures of the Drosophila Paired homodimer and the yeast a1/α2 heterodimer bound to DNA, along with a high-resolution study of a Drosophila eve-DNA complex, have deepened our understanding of how homeodomains locate their DNA targets.

Original languageEnglish (US)
Pages (from-to)62-68
Number of pages7
JournalCurrent Opinion in Structural Biology
Volume6
Issue number1
DOIs
StatePublished - Feb 1996

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Homeodomain interactions'. Together they form a unique fingerprint.

  • Cite this