TY - JOUR
T1 - Home environmental intervention in inner-city asthma
T2 - A randomized controlled clinical trial
AU - Eggleston, Peyton A.
AU - Butz, Arlene
AU - Rand, Cynthia
AU - Curtin-Brosnan, Jean
AU - Kanchanaraksa, Sukon
AU - Swartz, Lee
AU - Breysse, Patrick
AU - Buckley, Timothy
AU - Diette, Gregory
AU - Merriman, Barry
AU - Krishnan, Jerry A.
N1 - Funding Information:
* Departments of Pediatrics and Internal Medicine, the Johns Hopkins University School of Medicine, Baltimore, Maryland. † Departments of Environmental Health Science and Epidemiology, the Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland. This study was supported by grant R82672401 from the US Environmental Protection Agency, grant ES09606 from the National Institute of Environmental Health Sciences, grant HL058942 from the National Heart, Lung, and Blood Institute, and a grant from the US Environmental Protection Agency’s Science to Achieve Results (STAR) program. Received for publication February 28, 2005. Accepted for publication in revised form April 2, 2005.
PY - 2005/12
Y1 - 2005/12
N2 - Background: Airborne pollutants and indoor allergens increase asthma morbidity in inner-city children; therefore, reducing exposure, if feasible, should improve asthma morbidity. Objective: To conduct a randomized controlled trial of methods to reduce environmental pollutant and allergen exposure in the homes of asthmatic children living in the inner city. Methods: After the completion of questionnaires, spirometry and allergen skin tests, home inspection, and measurement of home air pollutant and allergen levels, 100 asthmatic children aged 6 to 12 years were randomized to the treatment group (home-based education, cockroach and rodent extermination, mattress and pillow encasings, and high-efficiency particulate air cleaner) or to the control group (treated at the end of the 1-year trial). Outcomes were evaluated by home evaluations at 6 and 12 months, clinic evaluation at 12 months, and multiple telephone interviews. Results: In the treatment group, 84% received cockroach extermination and 75% used the air cleaner. Levels of particulate matter 10 μm or smaller declined by up to 39% in the treatment group but increased in the control group (P < .001). Cockroach allergen levels decreased by 51% in the treatment group. Daytime symptoms increased in the control group and decreased in the treatment group (P = .04). Other measures of morbidity, such as spirometry findings, nighttime symptoms, and emergency department use, were not significantly changed. Conclusions: A tailored, multifaceted environmental treatment reduced airborne particulate matter and indoor allergen levels in inner-city homes, which, in turn, had a modest effect on morbidity.
AB - Background: Airborne pollutants and indoor allergens increase asthma morbidity in inner-city children; therefore, reducing exposure, if feasible, should improve asthma morbidity. Objective: To conduct a randomized controlled trial of methods to reduce environmental pollutant and allergen exposure in the homes of asthmatic children living in the inner city. Methods: After the completion of questionnaires, spirometry and allergen skin tests, home inspection, and measurement of home air pollutant and allergen levels, 100 asthmatic children aged 6 to 12 years were randomized to the treatment group (home-based education, cockroach and rodent extermination, mattress and pillow encasings, and high-efficiency particulate air cleaner) or to the control group (treated at the end of the 1-year trial). Outcomes were evaluated by home evaluations at 6 and 12 months, clinic evaluation at 12 months, and multiple telephone interviews. Results: In the treatment group, 84% received cockroach extermination and 75% used the air cleaner. Levels of particulate matter 10 μm or smaller declined by up to 39% in the treatment group but increased in the control group (P < .001). Cockroach allergen levels decreased by 51% in the treatment group. Daytime symptoms increased in the control group and decreased in the treatment group (P = .04). Other measures of morbidity, such as spirometry findings, nighttime symptoms, and emergency department use, were not significantly changed. Conclusions: A tailored, multifaceted environmental treatment reduced airborne particulate matter and indoor allergen levels in inner-city homes, which, in turn, had a modest effect on morbidity.
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U2 - 10.1016/S1081-1206(10)61012-5
DO - 10.1016/S1081-1206(10)61012-5
M3 - Article
C2 - 16400889
AN - SCOPUS:29444454721
SN - 1081-1206
VL - 95
SP - 518
EP - 524
JO - Annals of Allergy, Asthma and Immunology
JF - Annals of Allergy, Asthma and Immunology
IS - 6
ER -