Holt-Oram syndrome

Ann T. Smith, George H. Sack, George J. Taylor

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


The autosomal dominant association of upper extremity skeletal defects with congenital heart disease isknown as the Holt-Oram syndrome. We reviewed our experience with 39 affected patients of whom 15 were considered new mutations. Wide varieties of skeletal defects and congenital heart disease were observed, and the severity of skeletal involvement did not parallel that of cardiac disease. These patients demonstrate four previously unemphasized points: (1) There is a striking asymmetry of skeletal involvement, with the left side more severely affected. (2) Patients with skeletal defects alone can transmit both skeletal and cardiac defects to their children. (3) Hypoplastic peripheral vessels may be an associated abnormality and can result in difficulty with cardiac catheterization. (4) Electrocardiographic changes of terminal conduction delay in the right anterior chest leads were not uniformly present in patients with otherwise typical secundum atrial septal defects.2Dr. Sack supported in part by the Andrew Mellon Foundation and United States Public Health Service Grant 1 R01 CA Z0619-01.

Original languageEnglish (US)
Pages (from-to)538-543
Number of pages6
JournalThe Journal of pediatrics
Issue number4
StatePublished - Oct 1979
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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