Abstract
Purpose: Corneal curvature can be altered by shrinking stromal collagen with a pulsed solid-state holmium:YAG laser in a procedure termed laser thermokeratoplasty. Methods: The authors performed laser thermokeratoplasty in 40 human cadaver eyes using a ring pattern of 32 spots, each spot having a diameter of 300 μm. Results: The amount of induced corneal steepening decreased as ring diameter was increased in 1 mm increments, with 22.2 ± 3.3 and 3.7 ± 2.0 diopters (D) of central steepening with diameters of 3 and 7 mm, respectively. Results of histologic examination showed a cone-shaped zone of increased stromal hematoxylin uptake extending posteriorly for 90% of stromal thickness. Energy levels greater than those needed to induce topographic changes produced limited endothelial injury in rabbit corneas and, in some cases, intraocular inflammation. A computerized, finite element model of the globe demonstrated central corneal steepening as a result of heat-induced stromal contraction to a depth of 75% corneal thickness. Conclusions: These data support previous studies indicating that central corneal topography can be modified by heating corneal stroma in a controlled fashion with the mid-infrared holmium:YAG laser.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 752-761 |
| Number of pages | 10 |
| Journal | Ophthalmology |
| Volume | 100 |
| Issue number | 5 |
| State | Published - 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Holmium laser thermokeratoplasty. / Moreira, H.; Campos, M.; Sawusch, M. R.; McDonnell, J. M.; Sand, B.; McDonnell, Peter J.
In: Ophthalmology, Vol. 100, No. 5, 1993, p. 752-761.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Holmium laser thermokeratoplasty
AU - Moreira, H.
AU - Campos, M.
AU - Sawusch, M. R.
AU - McDonnell, J. M.
AU - Sand, B.
AU - McDonnell, Peter J
PY - 1993
Y1 - 1993
N2 - Purpose: Corneal curvature can be altered by shrinking stromal collagen with a pulsed solid-state holmium:YAG laser in a procedure termed laser thermokeratoplasty. Methods: The authors performed laser thermokeratoplasty in 40 human cadaver eyes using a ring pattern of 32 spots, each spot having a diameter of 300 μm. Results: The amount of induced corneal steepening decreased as ring diameter was increased in 1 mm increments, with 22.2 ± 3.3 and 3.7 ± 2.0 diopters (D) of central steepening with diameters of 3 and 7 mm, respectively. Results of histologic examination showed a cone-shaped zone of increased stromal hematoxylin uptake extending posteriorly for 90% of stromal thickness. Energy levels greater than those needed to induce topographic changes produced limited endothelial injury in rabbit corneas and, in some cases, intraocular inflammation. A computerized, finite element model of the globe demonstrated central corneal steepening as a result of heat-induced stromal contraction to a depth of 75% corneal thickness. Conclusions: These data support previous studies indicating that central corneal topography can be modified by heating corneal stroma in a controlled fashion with the mid-infrared holmium:YAG laser.
AB - Purpose: Corneal curvature can be altered by shrinking stromal collagen with a pulsed solid-state holmium:YAG laser in a procedure termed laser thermokeratoplasty. Methods: The authors performed laser thermokeratoplasty in 40 human cadaver eyes using a ring pattern of 32 spots, each spot having a diameter of 300 μm. Results: The amount of induced corneal steepening decreased as ring diameter was increased in 1 mm increments, with 22.2 ± 3.3 and 3.7 ± 2.0 diopters (D) of central steepening with diameters of 3 and 7 mm, respectively. Results of histologic examination showed a cone-shaped zone of increased stromal hematoxylin uptake extending posteriorly for 90% of stromal thickness. Energy levels greater than those needed to induce topographic changes produced limited endothelial injury in rabbit corneas and, in some cases, intraocular inflammation. A computerized, finite element model of the globe demonstrated central corneal steepening as a result of heat-induced stromal contraction to a depth of 75% corneal thickness. Conclusions: These data support previous studies indicating that central corneal topography can be modified by heating corneal stroma in a controlled fashion with the mid-infrared holmium:YAG laser.
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M3 - Article
C2 - 8493020
AN - SCOPUS:0027278172
VL - 100
SP - 752
EP - 761
JO - Ophthalmology
JF - Ophthalmology
SN - 0161-6420
IS - 5
ER -