Holmium laser thermokeratoplasty

H. Moreira, M. Campos, M. R. Sawusch, J. M. McDonnell, B. Sand, Peter J McDonnell

Research output: Contribution to journalArticle

Abstract

Purpose: Corneal curvature can be altered by shrinking stromal collagen with a pulsed solid-state holmium:YAG laser in a procedure termed laser thermokeratoplasty. Methods: The authors performed laser thermokeratoplasty in 40 human cadaver eyes using a ring pattern of 32 spots, each spot having a diameter of 300 μm. Results: The amount of induced corneal steepening decreased as ring diameter was increased in 1 mm increments, with 22.2 ± 3.3 and 3.7 ± 2.0 diopters (D) of central steepening with diameters of 3 and 7 mm, respectively. Results of histologic examination showed a cone-shaped zone of increased stromal hematoxylin uptake extending posteriorly for 90% of stromal thickness. Energy levels greater than those needed to induce topographic changes produced limited endothelial injury in rabbit corneas and, in some cases, intraocular inflammation. A computerized, finite element model of the globe demonstrated central corneal steepening as a result of heat-induced stromal contraction to a depth of 75% corneal thickness. Conclusions: These data support previous studies indicating that central corneal topography can be modified by heating corneal stroma in a controlled fashion with the mid-infrared holmium:YAG laser.

Original languageEnglish (US)
Pages (from-to)752-761
Number of pages10
JournalOphthalmology
Volume100
Issue number5
StatePublished - 1993
Externally publishedYes

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Solid-State Lasers
Lasers
Corneal Topography
Corneal Stroma
Hematoxylin
Cadaver
Cornea
Heating
Collagen
Hot Temperature
Rabbits
Inflammation
Wounds and Injuries

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Moreira, H., Campos, M., Sawusch, M. R., McDonnell, J. M., Sand, B., & McDonnell, P. J. (1993). Holmium laser thermokeratoplasty. Ophthalmology, 100(5), 752-761.

Holmium laser thermokeratoplasty. / Moreira, H.; Campos, M.; Sawusch, M. R.; McDonnell, J. M.; Sand, B.; McDonnell, Peter J.

In: Ophthalmology, Vol. 100, No. 5, 1993, p. 752-761.

Research output: Contribution to journalArticle

Moreira, H, Campos, M, Sawusch, MR, McDonnell, JM, Sand, B & McDonnell, PJ 1993, 'Holmium laser thermokeratoplasty', Ophthalmology, vol. 100, no. 5, pp. 752-761.
Moreira H, Campos M, Sawusch MR, McDonnell JM, Sand B, McDonnell PJ. Holmium laser thermokeratoplasty. Ophthalmology. 1993;100(5):752-761.
Moreira, H. ; Campos, M. ; Sawusch, M. R. ; McDonnell, J. M. ; Sand, B. ; McDonnell, Peter J. / Holmium laser thermokeratoplasty. In: Ophthalmology. 1993 ; Vol. 100, No. 5. pp. 752-761.
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