Hollow-Fiber Methodology for Pharmacokinetic/Pharmacodynamic Studies of Antimalarial Compounds

Emily Caton, Elizabeth Nenortas, Rahul P. Bakshi, Theresa A. Shapiro

Research output: Contribution to journalArticlepeer-review

Abstract

Knowledge of pharmacokinetic/pharmacodynamic (PK/PD) relationships can enhance the speed and economy of drug development by enabling informed and rational decisions at every step, from lead selection to clinical dosing. For anti-infective agents in particular, dynamic in vitro hollow-fiber cartridge experiments permit exquisite control of kinetic parameters and the study of their consequent impact on pharmacodynamic efficacy. Such information is of great interest for the cost-restricted but much-needed development of new antimalarial drugs, especially since the major human pathogen Plasmodium falciparum can be cultivated in vitro but is not readily available in animal models. This protocol describes the materials and procedures for determining the PK/PD relationships of antimalarial compounds.

Original languageEnglish (US)
Pages (from-to)29-58
Number of pages30
JournalCurrent protocols in chemical biology
Volume8
Issue number1
DOIs
StatePublished - Mar 16 2016

Keywords

  • Plasmodium falciparum
  • drug development
  • dynamic PK/PD
  • hollow-fiber cartridge system
  • malaria
  • pharmacodynamics
  • pharmacokinetics

ASJC Scopus subject areas

  • Medicine(all)

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