TY - JOUR
T1 - HLA Typing in Uveitis
T2 - Use and Misuse
AU - Zamecki, Katherine J.
AU - Jabs, Douglas A.
N1 - Funding Information:
Supported in part by an unrestricted grant from Research to Prevent Blindness, Inc, New York, New York . Douglas A. Jabs is Chairman of the Multicenter Uveitis Steroid Treatment (MUST) Trial supported by the National Eye Institute, Bethesda, Maryland. Bausch & Lomb, Rochester, New York, is providing a limited amount of drug for this study. Dr Jabs has acted as a consultant for Roche Pharmaceuticals, Ciba Vision, Bayer Corporation, EMMES Corporation, Novartis Pharmaceutical Corp, Centocor, Inc, and SmithKline Beecham. Currently, Dr Jabs is a consultant for Allergan, Abbott Laboratories, Genzyme Corporation, Novartis Pharmaceutical Corp, Roche Pharmaceuticals, and GlaxoSmithKline. Dr Jabs currently acts as a Data and Safety Monitoring Board (DSMB) member for Applied Genetic Technologies Corporation (AGTC). Involved in design of the study (D.A.J.); Conduct of the study (D.A.J., K.J.Z.); Collection of the data (K.J.Z.); Management of the data (D.A.J., K.J.Z.); Analysis of the data (K.J.Z., D.A.J.); Interpretation of the data (K.J.Z., D.A.J.); Preparation of the manuscript (K.J.Z.); Review of the manuscript (K.J.Z., D.A.J.); and Approval of the manuscript (K.J.Z., D.A.J.). The institutional review board waived the need for approval of this type of study.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2010/2/1
Y1 - 2010/2/1
N2 - Purpose: To evaluate the role of HLA typing as a diagnostic test in patients with uveitis. Design: Perspective derived from a literature review and analysis of reported results. Methods: Published data on the HLA associations of several uveitis entities and their prevalence among patients and the general population were used to calculate the positive predictive value of HLA testing as a diagnostic test for these disorders. Results: For nearly all diagnostic entities evaluated (including multiple sclerosis-associated intermediate uveitis, birdshot chorioretinitis, sympathetic ophthalmic, Behçet disease, and Vogt-Koyanagi-Harada disease), the positive predictive value was low (< 0.50), indicating the limited usefulness of routinely applied HLA typing as a diagnostic test. HLA-B27 testing may be of value in identifying a previously undiagnosed or misdiagnosed spondyloarthropathy among patients with recurrent acute anterior uveitis. Conclusions: In general, HLA typing has limited usefulness as a diagnostic test in patients with uveitis.
AB - Purpose: To evaluate the role of HLA typing as a diagnostic test in patients with uveitis. Design: Perspective derived from a literature review and analysis of reported results. Methods: Published data on the HLA associations of several uveitis entities and their prevalence among patients and the general population were used to calculate the positive predictive value of HLA testing as a diagnostic test for these disorders. Results: For nearly all diagnostic entities evaluated (including multiple sclerosis-associated intermediate uveitis, birdshot chorioretinitis, sympathetic ophthalmic, Behçet disease, and Vogt-Koyanagi-Harada disease), the positive predictive value was low (< 0.50), indicating the limited usefulness of routinely applied HLA typing as a diagnostic test. HLA-B27 testing may be of value in identifying a previously undiagnosed or misdiagnosed spondyloarthropathy among patients with recurrent acute anterior uveitis. Conclusions: In general, HLA typing has limited usefulness as a diagnostic test in patients with uveitis.
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U2 - 10.1016/j.ajo.2009.09.018
DO - 10.1016/j.ajo.2009.09.018
M3 - Article
C2 - 20103052
AN - SCOPUS:73549087880
SN - 0002-9394
VL - 149
SP - 189-193.e2
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 2
ER -