HLA typing in focal myositis

Kenji Sekiguchi, Fumio Kanda, Kenichi Oishi, Hirotoshi Hamaguchi, Kenichiro Nakazawa, Nobuya Maeda, Hiroyuki Ishihara, Kazuo Chihara

Research output: Contribution to journalArticle

Abstract

It is still controversial if idiopathic focal myositis is a part of systemic polymyositis. We present here four patients, including identical twins, with focal myositis accompanied by the same HLA typings. Gradually developing unilateral calf muscle pain was an initial symptom in all patients. Neither muscular weakness nor creatine kinase (CK) elevation was observed, while minimal inflammatory findings such as erythrocyte sedimentation rate (ESR) increase appeared in serum. Magnetic resonance imaging (MRI) revealed localized abnormalities of calf muscles. Biopsy specimen was characterized by perimysial and endomysial inflammatory infiltration consisted of T cells and macrophages and rare necrotic fibers. Corticosteroid administrations ameliorated their symptoms and signs, though recurrence occurred along with decreasing doses. HLA typings common to all patients were A2, B62, Cw3, and DQ3, whereas HLA-D DNA typings were DQB1*0303 for two patients, and DQB1*0302 for three patients. These findings suggest that at least some focal myositis may be a new disease unit, with a common genetic background but not a part of systemic polymyositis.

Original languageEnglish (US)
Pages (from-to)21-25
Number of pages5
JournalJournal of the Neurological Sciences
Volume227
Issue number1
DOIs
StatePublished - Dec 15 2004
Externally publishedYes

Fingerprint

Histocompatibility Testing
Myositis
Polymyositis
HLA-D Antigens
DNA Fingerprinting
Monozygotic Twins
Blood Sedimentation
Myalgia
Muscle Weakness
Creatine Kinase
varespladib methyl
Signs and Symptoms
Adrenal Cortex Hormones
Macrophages
Magnetic Resonance Imaging
T-Lymphocytes
Biopsy
Recurrence
Muscles
Serum

Keywords

  • Corticosteroid
  • Focal myositis
  • HLA
  • Inflammatory myopathy
  • Localized nodular myositis
  • Polymyositis

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Sekiguchi, K., Kanda, F., Oishi, K., Hamaguchi, H., Nakazawa, K., Maeda, N., ... Chihara, K. (2004). HLA typing in focal myositis. Journal of the Neurological Sciences, 227(1), 21-25. https://doi.org/10.1016/j.jns.2004.07.020

HLA typing in focal myositis. / Sekiguchi, Kenji; Kanda, Fumio; Oishi, Kenichi; Hamaguchi, Hirotoshi; Nakazawa, Kenichiro; Maeda, Nobuya; Ishihara, Hiroyuki; Chihara, Kazuo.

In: Journal of the Neurological Sciences, Vol. 227, No. 1, 15.12.2004, p. 21-25.

Research output: Contribution to journalArticle

Sekiguchi, K, Kanda, F, Oishi, K, Hamaguchi, H, Nakazawa, K, Maeda, N, Ishihara, H & Chihara, K 2004, 'HLA typing in focal myositis', Journal of the Neurological Sciences, vol. 227, no. 1, pp. 21-25. https://doi.org/10.1016/j.jns.2004.07.020
Sekiguchi K, Kanda F, Oishi K, Hamaguchi H, Nakazawa K, Maeda N et al. HLA typing in focal myositis. Journal of the Neurological Sciences. 2004 Dec 15;227(1):21-25. https://doi.org/10.1016/j.jns.2004.07.020
Sekiguchi, Kenji ; Kanda, Fumio ; Oishi, Kenichi ; Hamaguchi, Hirotoshi ; Nakazawa, Kenichiro ; Maeda, Nobuya ; Ishihara, Hiroyuki ; Chihara, Kazuo. / HLA typing in focal myositis. In: Journal of the Neurological Sciences. 2004 ; Vol. 227, No. 1. pp. 21-25.
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