HLA-Ig-based artificial antigen-presenting cells: Setting the terms of engagement

Mathias Oelke, Jonathan P. Schneck

Research output: Contribution to journalArticle

Abstract

Recent advances in molecular medicine have shown that soluble MHC-multimers can be valuable tools for both the stimulation of as well as the analysis of antigen-specific T cells in vitro. In this review, we describe the use of dimeric major histocompatibility complexes, HLA-Ig, to visualize antigen-specific T cells as well as their potential to stimulate immune responses as part of an artificial antigen-presenting cell (aAPC). The use of HLA-Ig-based aAPC represents an exciting new approach to generate antigen-specific CTL for adoptive immunotherapy that helps to overcome many of the obstacles associated with limitations in current approaches to adoptive immunotherapy.

Original languageEnglish (US)
Pages (from-to)243-251
Number of pages9
JournalClinical Immunology
Volume110
Issue number3
DOIs
StatePublished - Mar 2004

Keywords

  • Adoptive immunotherapy
  • CD8 CTL
  • Class I HLA
  • HLA-Ig dimer
  • Infectious diseases
  • Tumors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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