Abstract
Recent advances in molecular medicine have shown that soluble MHC-multimers can be valuable tools for both the stimulation of as well as the analysis of antigen-specific T cells in vitro. In this review, we describe the use of dimeric major histocompatibility complexes, HLA-Ig, to visualize antigen-specific T cells as well as their potential to stimulate immune responses as part of an artificial antigen-presenting cell (aAPC). The use of HLA-Ig-based aAPC represents an exciting new approach to generate antigen-specific CTL for adoptive immunotherapy that helps to overcome many of the obstacles associated with limitations in current approaches to adoptive immunotherapy.
Original language | English (US) |
---|---|
Pages (from-to) | 243-251 |
Number of pages | 9 |
Journal | Clinical Immunology |
Volume | 110 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2004 |
Keywords
- Adoptive immunotherapy
- CD8 CTL
- Class I HLA
- HLA-Ig dimer
- Infectious diseases
- Tumors
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology