HLA-DRB1 among patients with Vogt-Koyanagi-Harada disease in Saudi Arabia

Alia Iqniebi, Ameera Gaafar, Atia Sheereen, Abdullah Al-Suliman, Gamal Mohamed, Khaled Al-Hussein, Khalid F. Tabbara

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Vogt-Koyanagi-Harada (VKH) disease is an immune-mediated disorder with autoimmune insult directed against antigens associated with melanocytes. The genetic predisposition among VKH has not been explored in Saudi Arabia. So, the purpose of this study was to investigate the association of human leukocyte antigen (HLA)-DRB1 alleles to VKH patients and to clarify the molecular genetic mechanism underlying the susceptibility or resistance to VKH disease. Methods: Genomic DNA from a total of 30 patients with VKH and 29 control subjects was extracted from peripheral blood, and HLA-DRB1 alleles were typed by polymerase chain reaction and sequence based typing (SBT). Results: We found a statistically significant difference in the prevalence of HLA-DRB1 *0405 between the VKH patients and control subjects (p

Original languageEnglish (US)
Pages (from-to)1876-1880
Number of pages5
JournalMolecular Vision
Volume15
StatePublished - Sep 12 2009

ASJC Scopus subject areas

  • Ophthalmology

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