HLA-DR2 and Narcolepsy

Ronald E. Kramer, Dudley S. Dinner, William E. Braun, Andrea A. Zachary, Gary A. Teresi

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Tissue typing was performed on 14 narcoleptics as defined by both strict sleep laboratory and clinical criteria. Six of these patients were blacks from North America, a race underrepresented in previous studies. All patients were HLA-DR2-antigen positive and had the same HLA-DR2 subtype. Clinical severity of disease was not correlated with HLA-DR2 heterozygosity or (putative) homozygosity. This study confirms that the extremely high association between HLA-DR2 and narcolepsy holds across comparisons of the three races studied to date when both clinical and sleep laboratory data are used. The presence or absence of HLA-DR2 in patients presenting with hyper-somnolence may help support or exclude, respectively, a diagnosis of idiopathic narcolepsy.

Original languageEnglish (US)
Pages (from-to)853-855
Number of pages3
JournalArchives of neurology
Volume44
Issue number8
DOIs
StatePublished - Aug 1987

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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