HLA-DR2 and Narcolepsy

Ronald E. Kramer, Dudley S. Dinner, William E. Braun, Andrea A. Zachary, Gary A. Teresi

Research output: Contribution to journalArticlepeer-review

Abstract

Tissue typing was performed on 14 narcoleptics as defined by both strict sleep laboratory and clinical criteria. Six of these patients were blacks from North America, a race underrepresented in previous studies. All patients were HLA-DR2-antigen positive and had the same HLA-DR2 subtype. Clinical severity of disease was not correlated with HLA-DR2 heterozygosity or (putative) homozygosity. This study confirms that the extremely high association between HLA-DR2 and narcolepsy holds across comparisons of the three races studied to date when both clinical and sleep laboratory data are used. The presence or absence of HLA-DR2 in patients presenting with hyper-somnolence may help support or exclude, respectively, a diagnosis of idiopathic narcolepsy.

Original languageEnglish (US)
Pages (from-to)853-855
Number of pages3
JournalArchives of neurology
Volume44
Issue number8
DOIs
StatePublished - Aug 1987

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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