TY - JOUR
T1 - HLA-B alleles B∗15:01 and B∗15:02
T2 - Opposite association with hepatitis C virus infection in chinese voluntary blood donors
AU - Xiong, Huaping
AU - Huang, Jieting
AU - Rong, Xia
AU - Zhang, Ming
AU - Huang, Ke
AU - Xu, Ru
AU - Wang, Min
AU - Li, Chengyao
AU - Liao, Qiao
AU - Xia, Wenjie
AU - Luo, Guangping
AU - Ye, Xin
AU - Lu, Ling
AU - Fu, Yongshui
AU - Guo, Tai
AU - Nelson, Kenrad
N1 - Publisher Copyright:
© 2015 S. Karger AG, Basel.
PY - 2015/5/28
Y1 - 2015/5/28
N2 - Background: Although human leukocyte antigens (HLA) have been shown in association with the outcomes of hepatitis C virus (HCV) infection among different ethnic groups, such studies remain absent in China, where the HCV prevalence is higher than the global average. Methods: In this study, 426 HCV-infected and 709 uninfected blood donors were analyzed, among whom the HLA alleles were sequenced using a high-resolution genotyping method. Results: At the 2-digit level, none of the alleles showed a statistical difference between the HCV-infected and uninfected groups. However, at the 4-digit level, the HLA-B alleles B∗15:01 and B∗15:02 showed an opposite association with HCV infection, i.e. B∗15:01 was significantly higher in the HCV-infected group (odds ratio, OR = 1.561, p = 0.010), while B∗15:02 was significantly higher in the uninfected group (OR = 0.778, p = 0.016). We also identified a higher frequency of B∗13:02 in the HCV-infected group (OR = 1.515, p = 0.009) and a higher frequency of B∗07:05 in the uninfected group (OR = 0.299, p = 0.001). Conclusions: The frequencies of four HLA alleles, B∗07:05, B∗13:02, B∗15:01, and B∗15:02, were found to be significantly different between the HCV-infected and uninfected blood donors in China, revealing an inverse relation of B∗15:01 and B∗15:02 with HCV infection. This finding suggests that the ethnic genetic variations of HLA may greatly affect the host immune responses against HCV.
AB - Background: Although human leukocyte antigens (HLA) have been shown in association with the outcomes of hepatitis C virus (HCV) infection among different ethnic groups, such studies remain absent in China, where the HCV prevalence is higher than the global average. Methods: In this study, 426 HCV-infected and 709 uninfected blood donors were analyzed, among whom the HLA alleles were sequenced using a high-resolution genotyping method. Results: At the 2-digit level, none of the alleles showed a statistical difference between the HCV-infected and uninfected groups. However, at the 4-digit level, the HLA-B alleles B∗15:01 and B∗15:02 showed an opposite association with HCV infection, i.e. B∗15:01 was significantly higher in the HCV-infected group (odds ratio, OR = 1.561, p = 0.010), while B∗15:02 was significantly higher in the uninfected group (OR = 0.778, p = 0.016). We also identified a higher frequency of B∗13:02 in the HCV-infected group (OR = 1.515, p = 0.009) and a higher frequency of B∗07:05 in the uninfected group (OR = 0.299, p = 0.001). Conclusions: The frequencies of four HLA alleles, B∗07:05, B∗13:02, B∗15:01, and B∗15:02, were found to be significantly different between the HCV-infected and uninfected blood donors in China, revealing an inverse relation of B∗15:01 and B∗15:02 with HCV infection. This finding suggests that the ethnic genetic variations of HLA may greatly affect the host immune responses against HCV.
KW - Alleles
KW - Blood donor
KW - Chinese population
KW - Chronic infection
KW - Hepatitis C virus
KW - Human leukocyte antigens
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U2 - 10.1159/000369209
DO - 10.1159/000369209
M3 - Article
C2 - 25677350
AN - SCOPUS:84923084773
SN - 0300-5526
VL - 58
SP - 80
EP - 87
JO - Intervirology
JF - Intervirology
IS - 2
ER -