HIV type 1 variants with nevirapine resistance mutations are rarely detected in antiretroviral drug-naive African women with subtypes A, C, and D

Jessica D. Church, Sarah E. Hudelson, Laura A. Guay, Shu Chen, Donald R. Hoover, Neil Parkin, Susan A. Fiscus, Francis Mmiro, Philippa Musoke, Newton Kumwenda, J. Brooks Jackson, Taha E. Taha, Susan H. Eshleman

Research output: Contribution to journalArticlepeer-review

Abstract

K103N is frequently detected in HIV-infected women after single dose (SD) nevirapine (NVP). K103N-containing variants were detected more frequently by the ViroSeq HIV-1 Genotyping System in women with subtype C (69.2%) than subtypes A (19.4%, p < 0.0001) or D (36.1%, p < 0.0001). K103N-containing variants were also detected more frequently and at higher levels in women with subtype C by the LigAmp assay. In this report, we analyzed samples collected prior to or within hours after SD NVP administration from antiretroviral drug-naive African women with subtypes A, C, and D. Only 1/254 samples had an NVP resistance mutation detected with the ViroSeq system, and only 4/236 samples had K103N detected at >0.5% with the LigAmp assay [2/110 (1.8%) with subtype A, 1/46 (2.2%) with subtype C, and 1/80 (1.3%) with subtype D] (p = 0.92). We did not detect significant differences in the pre-NVP frequency of NVP resistance mutations or the pre-NVP levels of K103N-containing variants in women with subtypes A, C, and D that explain the dramatic subtype-based differences in emergence of HIV-1 variants with these mutations after SD NVP exposure.

Original languageEnglish (US)
Pages (from-to)764-768
Number of pages5
JournalAIDS research and human retroviruses
Volume23
Issue number6
DOIs
StatePublished - Jun 2007

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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