TY - JOUR
T1 - HIV type 1-mediated downregulation of HLA-B*57/B*5801 proteins on elite suppressor CD4+ T cells
AU - Sampah, Maame Efua S.
AU - Ceccato, Christina M.
AU - Blankson, Joel N.
PY - 2011/2/1
Y1 - 2011/2/1
N2 - Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain viral loads of <50 copies/ml without antiretroviral therapy. While HLA-B*57 and B*5801 alleles are overrepresented in ES, many HLA-B*57/B*5801 patients become chronic progressors (CP). We show here that HIV-1 infection results in similar levels of downregulation of HLA-B*57 and HLA-B*5801 molecules on primary CD4+ T cells from ES and CP. Thus, differences in HIV-1-mediated downregulation of HLA-B*57/B*5801 molecules do not distinguish ES from CP.
AB - Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain viral loads of <50 copies/ml without antiretroviral therapy. While HLA-B*57 and B*5801 alleles are overrepresented in ES, many HLA-B*57/B*5801 patients become chronic progressors (CP). We show here that HIV-1 infection results in similar levels of downregulation of HLA-B*57 and HLA-B*5801 molecules on primary CD4+ T cells from ES and CP. Thus, differences in HIV-1-mediated downregulation of HLA-B*57/B*5801 molecules do not distinguish ES from CP.
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U2 - 10.1089/aid.2010.0144
DO - 10.1089/aid.2010.0144
M3 - Article
C2 - 20919920
AN - SCOPUS:79951710673
SN - 0889-2229
VL - 27
SP - 183
EP - 186
JO - AIDS research and human retroviruses
JF - AIDS research and human retroviruses
IS - 2
ER -