HIV type 1-mediated downregulation of HLA-B*57/B*5801 proteins on elite suppressor CD4+ T cells

Maame Efua S. Sampah, Christina M. Ceccato, Joel N. Blankson

Research output: Contribution to journalArticle

Abstract

Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain viral loads of <50 copies/ml without antiretroviral therapy. While HLA-B*57 and B*5801 alleles are overrepresented in ES, many HLA-B*57/B*5801 patients become chronic progressors (CP). We show here that HIV-1 infection results in similar levels of downregulation of HLA-B*57 and HLA-B*5801 molecules on primary CD4+ T cells from ES and CP. Thus, differences in HIV-1-mediated downregulation of HLA-B*57/B*5801 molecules do not distinguish ES from CP.

Original languageEnglish (US)
Pages (from-to)183-186
Number of pages4
JournalAIDS research and human retroviruses
Volume27
Issue number2
DOIs
StatePublished - Feb 1 2011

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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