HIV suppression with stavudine 30 mg versus 40 mg in adults over 60 kg on antiretroviral therapy in South Africa

Christopher Hoffmann, Salome Charalambous, Katherine L. Fielding, Craig Innes, Richard E Chaisson, Alison D. Grant, Gavin J. Churchyard

Research output: Contribution to journalArticle

Abstract

In 2007, the WHO recommended a maximum stavudine dose of 30 mg. We compared virologic suppression among patients weighing more than 60 kg and receiving stavudine 30 mg (n = 110) versus 40 mg (n = 508) in community HIV clinics in South Africa, before and after guidelines changed. At 6 months, HIV RNA less than 400 copies/ml was achieved in 79% and 81% receiving 30 and 40 mg stavudine, respectively (χ, P = 0.6). In regression modeling, including baseline HIV RNA and nonnucleoside reverse transcriptase inhibitor agent, stavudine dose remained unassociated with suppression.

Original languageEnglish (US)
Pages (from-to)1784-1786
Number of pages3
JournalAIDS
Volume23
Issue number13
DOIs
StatePublished - Aug 24 2009

Fingerprint

Stavudine
South Africa
HIV
RNA
Reverse Transcriptase Inhibitors
Therapeutics
Guidelines

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

HIV suppression with stavudine 30 mg versus 40 mg in adults over 60 kg on antiretroviral therapy in South Africa. / Hoffmann, Christopher; Charalambous, Salome; Fielding, Katherine L.; Innes, Craig; Chaisson, Richard E; Grant, Alison D.; Churchyard, Gavin J.

In: AIDS, Vol. 23, No. 13, 24.08.2009, p. 1784-1786.

Research output: Contribution to journalArticle

Hoffmann, Christopher ; Charalambous, Salome ; Fielding, Katherine L. ; Innes, Craig ; Chaisson, Richard E ; Grant, Alison D. ; Churchyard, Gavin J. / HIV suppression with stavudine 30 mg versus 40 mg in adults over 60 kg on antiretroviral therapy in South Africa. In: AIDS. 2009 ; Vol. 23, No. 13. pp. 1784-1786.
@article{6861160fd4ca45fc8ede2a47af2e9a5f,
title = "HIV suppression with stavudine 30 mg versus 40 mg in adults over 60 kg on antiretroviral therapy in South Africa",
abstract = "In 2007, the WHO recommended a maximum stavudine dose of 30 mg. We compared virologic suppression among patients weighing more than 60 kg and receiving stavudine 30 mg (n = 110) versus 40 mg (n = 508) in community HIV clinics in South Africa, before and after guidelines changed. At 6 months, HIV RNA less than 400 copies/ml was achieved in 79{\%} and 81{\%} receiving 30 and 40 mg stavudine, respectively (χ, P = 0.6). In regression modeling, including baseline HIV RNA and nonnucleoside reverse transcriptase inhibitor agent, stavudine dose remained unassociated with suppression.",
author = "Christopher Hoffmann and Salome Charalambous and Fielding, {Katherine L.} and Craig Innes and Chaisson, {Richard E} and Grant, {Alison D.} and Churchyard, {Gavin J.}",
year = "2009",
month = "8",
day = "24",
doi = "10.1097/QAD.0b013e32832e0585",
language = "English (US)",
volume = "23",
pages = "1784--1786",
journal = "AIDS",
issn = "0269-9370",
publisher = "Lippincott Williams and Wilkins",
number = "13",

}

TY - JOUR

T1 - HIV suppression with stavudine 30 mg versus 40 mg in adults over 60 kg on antiretroviral therapy in South Africa

AU - Hoffmann, Christopher

AU - Charalambous, Salome

AU - Fielding, Katherine L.

AU - Innes, Craig

AU - Chaisson, Richard E

AU - Grant, Alison D.

AU - Churchyard, Gavin J.

PY - 2009/8/24

Y1 - 2009/8/24

N2 - In 2007, the WHO recommended a maximum stavudine dose of 30 mg. We compared virologic suppression among patients weighing more than 60 kg and receiving stavudine 30 mg (n = 110) versus 40 mg (n = 508) in community HIV clinics in South Africa, before and after guidelines changed. At 6 months, HIV RNA less than 400 copies/ml was achieved in 79% and 81% receiving 30 and 40 mg stavudine, respectively (χ, P = 0.6). In regression modeling, including baseline HIV RNA and nonnucleoside reverse transcriptase inhibitor agent, stavudine dose remained unassociated with suppression.

AB - In 2007, the WHO recommended a maximum stavudine dose of 30 mg. We compared virologic suppression among patients weighing more than 60 kg and receiving stavudine 30 mg (n = 110) versus 40 mg (n = 508) in community HIV clinics in South Africa, before and after guidelines changed. At 6 months, HIV RNA less than 400 copies/ml was achieved in 79% and 81% receiving 30 and 40 mg stavudine, respectively (χ, P = 0.6). In regression modeling, including baseline HIV RNA and nonnucleoside reverse transcriptase inhibitor agent, stavudine dose remained unassociated with suppression.

UR - http://www.scopus.com/inward/record.url?scp=69449104971&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69449104971&partnerID=8YFLogxK

U2 - 10.1097/QAD.0b013e32832e0585

DO - 10.1097/QAD.0b013e32832e0585

M3 - Article

VL - 23

SP - 1784

EP - 1786

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 13

ER -