HIV subtype is not associated with dementia among individuals with moderate and advanced immunosuppression in Kampala, Uganda

Ned Sacktor, Noeline Nakasujja, Andrew D. Redd, Jordyn Manucci, Oliver Laeyendecker, Sarah K. Wendel, Stephen F. Porcella, Craig Martens, Daniel Bruno, Richard L. Skolasky, Ozioma C. Okonkwo, Kevin Robertson, Seggane Musisi, Elly Katabira, Thomas C. Quinn

Research output: Contribution to journalArticlepeer-review

Abstract

HIV-associated neurocognitive disorders (HAND) are a common neurological manifestation of HIV infection. A previous study suggested that HIV dementia may be more common among patients with subtype D virus than among those with subtype A virus among HIV+ individuals with advanced immunosuppression. We conducted a study to evaluate the frequency of HIV dementia, and the association of HIV dementia with HIV subtype and compartmentalization among HIV+ individuals with moderate and advanced immunosuppression (CD4 lymphocyte count >150 cells/μL and <250 cells/μL). The study enrolled 117 antiretroviral naïve HIV+ individuals in Kampala, Uganda. HIV+ individuals received neurological, neuropsychological testing, and functional assessments, and gag and gp41 regions were subtyped. Subjects were considered infected with a specific subtype if both regions analyzed were from the same subtype. 41 % of the HIV+ individuals had HIV dementia (mean CD4 lymphocyte count = 233 cells/μL). 67 individuals had subtype A, 25 individuals had subtype D, 24 individuals were classified as A/D recombinants, and one individual had subtype C. There was no difference in the frequency of HIV dementia when stratified by HIV subtype A and D and no association with compartmentalization between the cerebrospinal fluid and peripheral blood. These results suggest that HIV dementia is common in HIV+ individuals in Uganda. There was no association between HIV subtype and dementia among HIV+ individuals with moderate and advanced immunosuppression. Future studies should be performed to confirm these results.

Original languageEnglish (US)
Pages (from-to)261-268
Number of pages8
JournalMetabolic Brain Disease
Volume29
Issue number2
DOIs
StatePublished - Jun 2014

Keywords

  • Clade
  • Dementia
  • HIV
  • Subtype
  • Uganda

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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