HIV-specific T-cell responses and generalized activation in HIV-1 infected long-term non-progressors and progressors from south India

Chinnambedu Ravichandran Swathirajan, Ramachandran Vignesh, Greer Waldrop, Uma Shanmugasundaram, Pannerselvam Nandagopal, Sunil Suhas Solomon, Amrose Pradeep, Shanmugam Saravanan, Kailapuri Gangatharan Murugavel

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Anti-viral cytokine expressions by cytotoxic T-cells and lower activation rates have been reported to correlate with suppressed HIV replication in long-term non-progressors (LTNP). Immune mechanisms underlying disease non-progression in LTNP might vary with HIV-1 subtype and geographical locations. Objective: This study evaluates cytokine expression and T-cells activation in relation to disease non-progression in LTNP. Methods: HIV-1 Subtype C infected LTNP (n=20) and progressors (n=15) were enrolled and flowcytometry assays were performed to study HIV-specific CD8 T-cells expressing IL-2, IFN-γ, TNF-α and MIP-1β against gag and env peptides. CD4+ T-cell activation was evaluated by surface expression of HLADR and CD38. Results: Proportions of cytokines studied did not differ significantly between LTNP and progressors, while contrasting correlations with disease progression markers were observed in LTNP. CD4+ T-cell activation rates were significantly lower in LTNP compared to progressors which indicate the potential role of T-cell activation rates in disease non-progression in LTNP. Conclusion: LTNP and progressors showed similar CD8+ T-cell responses, but final conclusions can be drawn only by comparing multiple immune factors in larger LTNP cohort with HIV-1 infected individuals at various levels of disease progression. A possible role of HIV-1 subtype variation and ethnic differences in addition to host-genetic and viral factors cannot be ruled out.

Original languageEnglish (US)
Pages (from-to)302-314
Number of pages13
JournalCurrent HIV research
Volume16
Issue number4
DOIs
StatePublished - 2018

Keywords

  • Antiviral cytokine response in HIV LTNP
  • CD38
  • HIV LTNP
  • HIV non-progression
  • HLADR
  • T-cell activation in HIV LTNP

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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