HIV replication and latency in monocytes and macrophages

Research output: Contribution to journalReview articlepeer-review

Abstract

The relevance of monocyte and macrophage reservoirs in virally suppressed people with HIV (vsPWH) has previously been debatable. Macrophages were assumed to have a moderate life span and lack self-renewing potential. However, recent studies have challenged this dogma and now suggest an important role of these cell as long-lived HIV reservoirs. Lentiviruses have a long-documented association with macrophages and abundant evidence exists that macrophages are important target cells for HIV in vivo. A critical understanding of HIV infection, replication, and latency in macrophages is needed in order to determine the appropriate method of measuring and eliminating this cellular reservoir. This review provides a brief discussion of the biology and acute and chronic infection of monocytes and macrophages, with a more substantial focus on replication, latency and measurement of the reservoir in cells of myeloid origin.

Original languageEnglish (US)
Article number101472
JournalSeminars in immunology
DOIs
StateAccepted/In press - 2021

Keywords

  • HIV
  • Latency
  • Macrophages
  • Replication
  • SIV

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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