HIV-Related Pneumonia Care in Older Patients Hospitalized in the Early HAART Era

Ashish Sureka, Jorge P. Parada, Maria Deloria Knoll, Joan S. Chmiel, Laura Phan, Thomas M. Lyons, Shirin Ali, Paul R. Yarnold, Robert A. Weinstein, Jack A. DeHovitz, Jeffrey M. Jacobson, Matthew B. Goetz, Rafael E. Campo, Dan Berland, Charles L. Bennett, Constance R. Uphold

Research output: Contribution to journalArticle

Abstract

Age-related variations in care have been identified for HIV-associated Pneumocystis carinii pneumonia (PCP) in both the 1980s and 1990s. We evaluated if age-related variations affected all aspects of HIV-specific and non-HIV-specific care for HIV-infected individuals with PCP or community-acquired pneumonia (CAP), or whether age-related variations were primarily limited to HIV-specific aspects of care. Subjects were HIV-infected persons with PCP (n = 1855) or CAP (n = 1415) hospitalized in 8 cities from 1995 to 1997. Nine percent of our study patients had received protease inhibitors and 39% had received any type of antiretroviral therapy prior to hospitalization. Data were abstracted from medical records and included severity of illness, HIV-specific aspects of care (initiation of PCP medications), general measures of care [initiation of CAP medications, intubation, and intensive care units (ICU)], and in-patient mortality. Compared to younger patients, pneumonia patients 50 years of age or older were significantly more likely to: be severely ill (PCP, 20.4% vs. 10.4%; CAP, 27.5% vs. 14.9%; each p = 0.001), receive ICU care (PCP, 22.0% vs. 12.8%, p = 0.002; CAP: 15.1% vs. 9.4%; p = 0.02), and be intubated (PCP, 14.6% vs. 8.4%, p = 0. 01; CAP, 9.9% vs. 5.6%, p = 0.03). Compared to younger patients, older patients (≥50 years) had similar rates of timely medications for CAP (48.5% vs. 50.8%) but had lower rates of receiving anti-PCP medications (85.8% vs. 92.9%, p = 0.002). Differences by age in timely initiation of PCP medications, ICU use, and intubation were limited to the nonseverely ill patients. Older hospitalized patients were more likely to die (PCP, 18.3% vs. 10.4%; CAP, 13.4% vs. 8.5%; each p <0.05). After adjustment for disease severity and timeliness of antibiotic use, mortality rates were similar for both age groups. Physicians should develop strategies that increase awareness of the possibility of HIV infection in older individuals.

Original languageEnglish (US)
Pages (from-to)99-107
Number of pages9
JournalAIDS Patient Care and STDs
Volume18
Issue number2
DOIs
StatePublished - Feb 2004
Externally publishedYes

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Pneumocystis Pneumonia
Highly Active Antiretroviral Therapy
Pneumonia
HIV
Intensive Care Units
Intubation
Mortality
Protease Inhibitors
HIV Infections
Medical Records
Hospitalization
Age Groups
Anti-Bacterial Agents
Physicians

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Leadership and Management
  • Nursing(all)

Cite this

Sureka, A., Parada, J. P., Knoll, M. D., Chmiel, J. S., Phan, L., Lyons, T. M., ... Uphold, C. R. (2004). HIV-Related Pneumonia Care in Older Patients Hospitalized in the Early HAART Era. AIDS Patient Care and STDs, 18(2), 99-107. https://doi.org/10.1089/108729104322802524

HIV-Related Pneumonia Care in Older Patients Hospitalized in the Early HAART Era. / Sureka, Ashish; Parada, Jorge P.; Knoll, Maria Deloria; Chmiel, Joan S.; Phan, Laura; Lyons, Thomas M.; Ali, Shirin; Yarnold, Paul R.; Weinstein, Robert A.; DeHovitz, Jack A.; Jacobson, Jeffrey M.; Goetz, Matthew B.; Campo, Rafael E.; Berland, Dan; Bennett, Charles L.; Uphold, Constance R.

In: AIDS Patient Care and STDs, Vol. 18, No. 2, 02.2004, p. 99-107.

Research output: Contribution to journalArticle

Sureka, A, Parada, JP, Knoll, MD, Chmiel, JS, Phan, L, Lyons, TM, Ali, S, Yarnold, PR, Weinstein, RA, DeHovitz, JA, Jacobson, JM, Goetz, MB, Campo, RE, Berland, D, Bennett, CL & Uphold, CR 2004, 'HIV-Related Pneumonia Care in Older Patients Hospitalized in the Early HAART Era', AIDS Patient Care and STDs, vol. 18, no. 2, pp. 99-107. https://doi.org/10.1089/108729104322802524
Sureka, Ashish ; Parada, Jorge P. ; Knoll, Maria Deloria ; Chmiel, Joan S. ; Phan, Laura ; Lyons, Thomas M. ; Ali, Shirin ; Yarnold, Paul R. ; Weinstein, Robert A. ; DeHovitz, Jack A. ; Jacobson, Jeffrey M. ; Goetz, Matthew B. ; Campo, Rafael E. ; Berland, Dan ; Bennett, Charles L. ; Uphold, Constance R. / HIV-Related Pneumonia Care in Older Patients Hospitalized in the Early HAART Era. In: AIDS Patient Care and STDs. 2004 ; Vol. 18, No. 2. pp. 99-107.
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