HIV protease inhibitors inhibit the development of preerythrocytic-stage Plasmodium parasites

Charlotte V. Hobbs, Tatiana Voza, Alida Coppi, Brian Kirmse, Kennan Marsh, William Borkowsky, Photini Sinnis

Research output: Contribution to journalArticle

Abstract

Recent studies have demonstrated that human immunodeficiency virus (HIV) protease inhibitors (PIs) exert inhibitory effects on erythrocytic stages of the human-malaria parasite Plasmodium falciparum in vitro and on erythrocytic stages of the rodent-malaria parasite Plasmodium chabaudi in vivo. Although it remains unclear how HIV PIs inhibit the parasite, the effect seen on parasite development in the erythrocytic stages is potent. The effect on preerythrocytic stages has not yet been investigated. Using the rodent parasite Plasmodium berghei, we screened a panel of HIV PIs in vitro for effects on the preerythrocytic stages. Our data indicated that the HIV PIs lopinavir and saquinavir affect preerythrocytic-stage parasite development in vitro. We then evaluated the effect of HIV PIs on preerythrocytic stages in vivo using the rodent parasite Plasmodium yoelii. We found that lopinavir/ritonavir had a dose-dependent effect on liver-stage parasite development. Given that sub-Saharan Africa is where the HIV/AIDS pandemic intersects with malaria, these results merit analysis in clinical settings.

Original languageEnglish (US)
Pages (from-to)134-141
Number of pages8
JournalJournal of Infectious Diseases
Volume199
Issue number1
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

Fingerprint

Plasmodium
Protease Inhibitors
Parasites
HIV
Lopinavir
Rodentia
Malaria
Plasmodium chabaudi
Plasmodium yoelii
Saquinavir
Plasmodium berghei
Ritonavir
Falciparum Malaria
Africa South of the Sahara
Pandemics
Acquired Immunodeficiency Syndrome
Liver

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

HIV protease inhibitors inhibit the development of preerythrocytic-stage Plasmodium parasites. / Hobbs, Charlotte V.; Voza, Tatiana; Coppi, Alida; Kirmse, Brian; Marsh, Kennan; Borkowsky, William; Sinnis, Photini.

In: Journal of Infectious Diseases, Vol. 199, No. 1, 01.01.2009, p. 134-141.

Research output: Contribution to journalArticle

Hobbs, Charlotte V. ; Voza, Tatiana ; Coppi, Alida ; Kirmse, Brian ; Marsh, Kennan ; Borkowsky, William ; Sinnis, Photini. / HIV protease inhibitors inhibit the development of preerythrocytic-stage Plasmodium parasites. In: Journal of Infectious Diseases. 2009 ; Vol. 199, No. 1. pp. 134-141.
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