HIV prevention efforts and incidence of HIV in Uganda

M. K. Grabowski, D. M. Serwadda, R. H. Gray, G. Nakigozi, G. Kigozi, J. Kagaayi, R. Ssekubugu, F. Nalugoda, J. Lessler, T. Lutalo, R. M. Galiwango, F. Makumbi, X. Kong, D. Kabatesi, S. T. Alamo, S. Wiersma, N. K. Sewankambo, A. A.R. Tobian, O. Laeyendecker, T. C. QuinnS. J. Reynolds, M. J. Wawer, L. W. Chang

Research output: Contribution to journalArticle

Abstract

BACKGROUND To assess the effect of a combination strategy for prevention of human immunodeficiency virus (HIV) on the incidence of HIV infection, we analyzed the association between the incidence of HIV and the scale-up of antiretroviral therapy (ART) and medical male circumcision in Rakai, Uganda. Changes in population-level viral-load suppression and sexual behaviors were also examined. METHODS Between 1999 and 2016, data were collected from 30 communities with the use of 12 surveys in the Rakai Community Cohort Study, an open, population-based cohort of persons 15 to 49 years of age. We assessed trends in the incidence of HIV on the basis of observed seroconversion data, participant-reported use of ART, participantreported male circumcision, viral-load suppression, and sexual behaviors. RESULTS In total, 33,937 study participants contributed 103,011 person-visits. A total of 17,870 persons who were initially HIV-negative were followed for 94,427 person-years; among these persons, 931 seroconversions were observed. ART was introduced in 2004, and by 2016, ART coverage was 69% (72% among women vs. 61% among men, P<0.001). HIV viral-load suppression among all HIV-positive persons increased from 42% in 2009 to 75% by 2016 (P<0.001). Male circumcision coverage increased from 15% in 1999 to 59% by 2016 (P<0.001). The percentage of adolescents 15 to 19 years of age who reported never having initiated sex (i.e., delayed sexual debut) increased from 30% in 1999 to 55% in 2016 (P<0.001). By 2016, the mean incidence of HIV infection had declined by 42% relative to the period before 2006 (i.e., before the scale-up of the combination strategy for HIV prevention) - from 1.17 cases per 100 person-years to 0.66 cases per 100 person-years (adjusted incidence rate ratio, 0.58; 95% confidence interval [CI], 0.45 to 0.76); declines were greater among men (adjusted incidence rate ratio, 0.46; 95% CI, 0.29 to 0.73) than among women (adjusted incidence rate ratio, 0.68; 95% CI, 0.50 to 0.94). CONCLUSIONS In this longitudinal study, the incidence of HIV infection declined significantly with the scale-up of a combination strategy for HIV prevention, which provides empirical evidence that interventions for HIV prevention can have a populationlevel effect. However, additional efforts are needed to overcome disparities according to sex and to achieve greater reductions in the incidence of HIV infection.

Original languageEnglish (US)
Pages (from-to)2154-2166
Number of pages13
JournalNew England Journal of Medicine
Volume377
Issue number22
DOIs
StatePublished - Nov 30 2017

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Uganda
HIV
Incidence
Virus Diseases
Male Circumcision
Viral Load
Confidence Intervals
Sexual Behavior
Therapeutics
Population
Longitudinal Studies
Cohort Studies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

HIV prevention efforts and incidence of HIV in Uganda. / Grabowski, M. K.; Serwadda, D. M.; Gray, R. H.; Nakigozi, G.; Kigozi, G.; Kagaayi, J.; Ssekubugu, R.; Nalugoda, F.; Lessler, J.; Lutalo, T.; Galiwango, R. M.; Makumbi, F.; Kong, X.; Kabatesi, D.; Alamo, S. T.; Wiersma, S.; Sewankambo, N. K.; Tobian, A. A.R.; Laeyendecker, O.; Quinn, T. C.; Reynolds, S. J.; Wawer, M. J.; Chang, L. W.

In: New England Journal of Medicine, Vol. 377, No. 22, 30.11.2017, p. 2154-2166.

Research output: Contribution to journalArticle

Grabowski, MK, Serwadda, DM, Gray, RH, Nakigozi, G, Kigozi, G, Kagaayi, J, Ssekubugu, R, Nalugoda, F, Lessler, J, Lutalo, T, Galiwango, RM, Makumbi, F, Kong, X, Kabatesi, D, Alamo, ST, Wiersma, S, Sewankambo, NK, Tobian, AAR, Laeyendecker, O, Quinn, TC, Reynolds, SJ, Wawer, MJ & Chang, LW 2017, 'HIV prevention efforts and incidence of HIV in Uganda', New England Journal of Medicine, vol. 377, no. 22, pp. 2154-2166. https://doi.org/10.1056/NEJMoa1702150
Grabowski, M. K. ; Serwadda, D. M. ; Gray, R. H. ; Nakigozi, G. ; Kigozi, G. ; Kagaayi, J. ; Ssekubugu, R. ; Nalugoda, F. ; Lessler, J. ; Lutalo, T. ; Galiwango, R. M. ; Makumbi, F. ; Kong, X. ; Kabatesi, D. ; Alamo, S. T. ; Wiersma, S. ; Sewankambo, N. K. ; Tobian, A. A.R. ; Laeyendecker, O. ; Quinn, T. C. ; Reynolds, S. J. ; Wawer, M. J. ; Chang, L. W. / HIV prevention efforts and incidence of HIV in Uganda. In: New England Journal of Medicine. 2017 ; Vol. 377, No. 22. pp. 2154-2166.
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abstract = "BACKGROUND To assess the effect of a combination strategy for prevention of human immunodeficiency virus (HIV) on the incidence of HIV infection, we analyzed the association between the incidence of HIV and the scale-up of antiretroviral therapy (ART) and medical male circumcision in Rakai, Uganda. Changes in population-level viral-load suppression and sexual behaviors were also examined. METHODS Between 1999 and 2016, data were collected from 30 communities with the use of 12 surveys in the Rakai Community Cohort Study, an open, population-based cohort of persons 15 to 49 years of age. We assessed trends in the incidence of HIV on the basis of observed seroconversion data, participant-reported use of ART, participantreported male circumcision, viral-load suppression, and sexual behaviors. RESULTS In total, 33,937 study participants contributed 103,011 person-visits. A total of 17,870 persons who were initially HIV-negative were followed for 94,427 person-years; among these persons, 931 seroconversions were observed. ART was introduced in 2004, and by 2016, ART coverage was 69{\%} (72{\%} among women vs. 61{\%} among men, P<0.001). HIV viral-load suppression among all HIV-positive persons increased from 42{\%} in 2009 to 75{\%} by 2016 (P<0.001). Male circumcision coverage increased from 15{\%} in 1999 to 59{\%} by 2016 (P<0.001). The percentage of adolescents 15 to 19 years of age who reported never having initiated sex (i.e., delayed sexual debut) increased from 30{\%} in 1999 to 55{\%} in 2016 (P<0.001). By 2016, the mean incidence of HIV infection had declined by 42{\%} relative to the period before 2006 (i.e., before the scale-up of the combination strategy for HIV prevention) - from 1.17 cases per 100 person-years to 0.66 cases per 100 person-years (adjusted incidence rate ratio, 0.58; 95{\%} confidence interval [CI], 0.45 to 0.76); declines were greater among men (adjusted incidence rate ratio, 0.46; 95{\%} CI, 0.29 to 0.73) than among women (adjusted incidence rate ratio, 0.68; 95{\%} CI, 0.50 to 0.94). CONCLUSIONS In this longitudinal study, the incidence of HIV infection declined significantly with the scale-up of a combination strategy for HIV prevention, which provides empirical evidence that interventions for HIV prevention can have a populationlevel effect. However, additional efforts are needed to overcome disparities according to sex and to achieve greater reductions in the incidence of HIV infection.",
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TY - JOUR

T1 - HIV prevention efforts and incidence of HIV in Uganda

AU - Grabowski, M. K.

AU - Serwadda, D. M.

AU - Gray, R. H.

AU - Nakigozi, G.

AU - Kigozi, G.

AU - Kagaayi, J.

AU - Ssekubugu, R.

AU - Nalugoda, F.

AU - Lessler, J.

AU - Lutalo, T.

AU - Galiwango, R. M.

AU - Makumbi, F.

AU - Kong, X.

AU - Kabatesi, D.

AU - Alamo, S. T.

AU - Wiersma, S.

AU - Sewankambo, N. K.

AU - Tobian, A. A.R.

AU - Laeyendecker, O.

AU - Quinn, T. C.

AU - Reynolds, S. J.

AU - Wawer, M. J.

AU - Chang, L. W.

PY - 2017/11/30

Y1 - 2017/11/30

N2 - BACKGROUND To assess the effect of a combination strategy for prevention of human immunodeficiency virus (HIV) on the incidence of HIV infection, we analyzed the association between the incidence of HIV and the scale-up of antiretroviral therapy (ART) and medical male circumcision in Rakai, Uganda. Changes in population-level viral-load suppression and sexual behaviors were also examined. METHODS Between 1999 and 2016, data were collected from 30 communities with the use of 12 surveys in the Rakai Community Cohort Study, an open, population-based cohort of persons 15 to 49 years of age. We assessed trends in the incidence of HIV on the basis of observed seroconversion data, participant-reported use of ART, participantreported male circumcision, viral-load suppression, and sexual behaviors. RESULTS In total, 33,937 study participants contributed 103,011 person-visits. A total of 17,870 persons who were initially HIV-negative were followed for 94,427 person-years; among these persons, 931 seroconversions were observed. ART was introduced in 2004, and by 2016, ART coverage was 69% (72% among women vs. 61% among men, P<0.001). HIV viral-load suppression among all HIV-positive persons increased from 42% in 2009 to 75% by 2016 (P<0.001). Male circumcision coverage increased from 15% in 1999 to 59% by 2016 (P<0.001). The percentage of adolescents 15 to 19 years of age who reported never having initiated sex (i.e., delayed sexual debut) increased from 30% in 1999 to 55% in 2016 (P<0.001). By 2016, the mean incidence of HIV infection had declined by 42% relative to the period before 2006 (i.e., before the scale-up of the combination strategy for HIV prevention) - from 1.17 cases per 100 person-years to 0.66 cases per 100 person-years (adjusted incidence rate ratio, 0.58; 95% confidence interval [CI], 0.45 to 0.76); declines were greater among men (adjusted incidence rate ratio, 0.46; 95% CI, 0.29 to 0.73) than among women (adjusted incidence rate ratio, 0.68; 95% CI, 0.50 to 0.94). CONCLUSIONS In this longitudinal study, the incidence of HIV infection declined significantly with the scale-up of a combination strategy for HIV prevention, which provides empirical evidence that interventions for HIV prevention can have a populationlevel effect. However, additional efforts are needed to overcome disparities according to sex and to achieve greater reductions in the incidence of HIV infection.

AB - BACKGROUND To assess the effect of a combination strategy for prevention of human immunodeficiency virus (HIV) on the incidence of HIV infection, we analyzed the association between the incidence of HIV and the scale-up of antiretroviral therapy (ART) and medical male circumcision in Rakai, Uganda. Changes in population-level viral-load suppression and sexual behaviors were also examined. METHODS Between 1999 and 2016, data were collected from 30 communities with the use of 12 surveys in the Rakai Community Cohort Study, an open, population-based cohort of persons 15 to 49 years of age. We assessed trends in the incidence of HIV on the basis of observed seroconversion data, participant-reported use of ART, participantreported male circumcision, viral-load suppression, and sexual behaviors. RESULTS In total, 33,937 study participants contributed 103,011 person-visits. A total of 17,870 persons who were initially HIV-negative were followed for 94,427 person-years; among these persons, 931 seroconversions were observed. ART was introduced in 2004, and by 2016, ART coverage was 69% (72% among women vs. 61% among men, P<0.001). HIV viral-load suppression among all HIV-positive persons increased from 42% in 2009 to 75% by 2016 (P<0.001). Male circumcision coverage increased from 15% in 1999 to 59% by 2016 (P<0.001). The percentage of adolescents 15 to 19 years of age who reported never having initiated sex (i.e., delayed sexual debut) increased from 30% in 1999 to 55% in 2016 (P<0.001). By 2016, the mean incidence of HIV infection had declined by 42% relative to the period before 2006 (i.e., before the scale-up of the combination strategy for HIV prevention) - from 1.17 cases per 100 person-years to 0.66 cases per 100 person-years (adjusted incidence rate ratio, 0.58; 95% confidence interval [CI], 0.45 to 0.76); declines were greater among men (adjusted incidence rate ratio, 0.46; 95% CI, 0.29 to 0.73) than among women (adjusted incidence rate ratio, 0.68; 95% CI, 0.50 to 0.94). CONCLUSIONS In this longitudinal study, the incidence of HIV infection declined significantly with the scale-up of a combination strategy for HIV prevention, which provides empirical evidence that interventions for HIV prevention can have a populationlevel effect. However, additional efforts are needed to overcome disparities according to sex and to achieve greater reductions in the incidence of HIV infection.

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