HIV prevalence and incidence estimates among blood donors in five regions in China

for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III)

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Previous data, although scant, indicated that the incidence of HIV in China has increased over the past decade. There is a growing concern about the impact of the HIV epidemic on blood safety. METHODS AND MATERIALS: We used donation data from five geographically-disperse blood centers in 2013-2016 participating in the Recipient Epidemiology and Donor Evaluation Study-III (REDS–III) China program to estimate HIV prevalence and incidence among blood donors. Multivariable logistic regression model was used to examine factors associated with HIV infection in Chinese blood donors. RESULTS: The overall HIV prevalence among first-time donors from 2013 through 2016 was 68.04 per 100,000 donors (95% CI 61.68–74.40). The HIV incidence rate was estimated to be 37.93 per 100,000 person-years (95% CI 30.62–46.97) among first-time donors and 20.55 per 100,000 person-years (95% CI 16.95–24.91) among repeat donors. There was substantial variation in HIV prevalence and incidence rates across blood centers. Multivariable logistic regression results showed that among first-time donors, being male, older than 25 years, minority ethnicity, less than college education, and certain occupations (commercial services, factory workers, retired, unemployed, or self-employed) were associated with positive HIV confirmatory testing results. CONCLUSION: HIV prevalence and incidence among blood donors remain low in the selected five regions in China; however, an increasing trend is observed at some blood centers. It is important to monitor HIV epidemiology in Chinese blood donors on a continuous basis, especially among populations and regions of higher risk.

Original languageEnglish (US)
Pages (from-to)117-125
Number of pages9
JournalTransfusion
Volume60
Issue number1
DOIs
StatePublished - Jan 1 2020

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Blood Donors
China
HIV
Incidence
Tissue Donors
Logistic Models
Epidemiology
Blood Safety
Occupations
HIV Infections
Education
Population

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

Cite this

for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) (2020). HIV prevalence and incidence estimates among blood donors in five regions in China. Transfusion, 60(1), 117-125. https://doi.org/10.1111/trf.15636

HIV prevalence and incidence estimates among blood donors in five regions in China. / for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).

In: Transfusion, Vol. 60, No. 1, 01.01.2020, p. 117-125.

Research output: Contribution to journalArticle

for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) 2020, 'HIV prevalence and incidence estimates among blood donors in five regions in China', Transfusion, vol. 60, no. 1, pp. 117-125. https://doi.org/10.1111/trf.15636
for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). HIV prevalence and incidence estimates among blood donors in five regions in China. Transfusion. 2020 Jan 1;60(1):117-125. https://doi.org/10.1111/trf.15636
for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). / HIV prevalence and incidence estimates among blood donors in five regions in China. In: Transfusion. 2020 ; Vol. 60, No. 1. pp. 117-125.
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abstract = "BACKGROUND: Previous data, although scant, indicated that the incidence of HIV in China has increased over the past decade. There is a growing concern about the impact of the HIV epidemic on blood safety. METHODS AND MATERIALS: We used donation data from five geographically-disperse blood centers in 2013-2016 participating in the Recipient Epidemiology and Donor Evaluation Study-III (REDS–III) China program to estimate HIV prevalence and incidence among blood donors. Multivariable logistic regression model was used to examine factors associated with HIV infection in Chinese blood donors. RESULTS: The overall HIV prevalence among first-time donors from 2013 through 2016 was 68.04 per 100,000 donors (95{\%} CI 61.68–74.40). The HIV incidence rate was estimated to be 37.93 per 100,000 person-years (95{\%} CI 30.62–46.97) among first-time donors and 20.55 per 100,000 person-years (95{\%} CI 16.95–24.91) among repeat donors. There was substantial variation in HIV prevalence and incidence rates across blood centers. Multivariable logistic regression results showed that among first-time donors, being male, older than 25 years, minority ethnicity, less than college education, and certain occupations (commercial services, factory workers, retired, unemployed, or self-employed) were associated with positive HIV confirmatory testing results. CONCLUSION: HIV prevalence and incidence among blood donors remain low in the selected five regions in China; however, an increasing trend is observed at some blood centers. It is important to monitor HIV epidemiology in Chinese blood donors on a continuous basis, especially among populations and regions of higher risk.",
author = "{for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III)} and Ling Shi and Yu Liu and Jingxing Wang and Peibin Zeng and Zhan Gao and Shaoli Wang and Ping Fu and Jing Liu and Wei Mao and Weilan He and Hongli Ma and Mei Huang and Jianhua Wan and Dan Liao and Donald Brambilla and Marian Sullivan and Shimian Zou and Paul Ness and Miao He and Hua Shan",
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T1 - HIV prevalence and incidence estimates among blood donors in five regions in China

AU - for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III)

AU - Shi, Ling

AU - Liu, Yu

AU - Wang, Jingxing

AU - Zeng, Peibin

AU - Gao, Zhan

AU - Wang, Shaoli

AU - Fu, Ping

AU - Liu, Jing

AU - Mao, Wei

AU - He, Weilan

AU - Ma, Hongli

AU - Huang, Mei

AU - Wan, Jianhua

AU - Liao, Dan

AU - Brambilla, Donald

AU - Sullivan, Marian

AU - Zou, Shimian

AU - Ness, Paul

AU - He, Miao

AU - Shan, Hua

PY - 2020/1/1

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N2 - BACKGROUND: Previous data, although scant, indicated that the incidence of HIV in China has increased over the past decade. There is a growing concern about the impact of the HIV epidemic on blood safety. METHODS AND MATERIALS: We used donation data from five geographically-disperse blood centers in 2013-2016 participating in the Recipient Epidemiology and Donor Evaluation Study-III (REDS–III) China program to estimate HIV prevalence and incidence among blood donors. Multivariable logistic regression model was used to examine factors associated with HIV infection in Chinese blood donors. RESULTS: The overall HIV prevalence among first-time donors from 2013 through 2016 was 68.04 per 100,000 donors (95% CI 61.68–74.40). The HIV incidence rate was estimated to be 37.93 per 100,000 person-years (95% CI 30.62–46.97) among first-time donors and 20.55 per 100,000 person-years (95% CI 16.95–24.91) among repeat donors. There was substantial variation in HIV prevalence and incidence rates across blood centers. Multivariable logistic regression results showed that among first-time donors, being male, older than 25 years, minority ethnicity, less than college education, and certain occupations (commercial services, factory workers, retired, unemployed, or self-employed) were associated with positive HIV confirmatory testing results. CONCLUSION: HIV prevalence and incidence among blood donors remain low in the selected five regions in China; however, an increasing trend is observed at some blood centers. It is important to monitor HIV epidemiology in Chinese blood donors on a continuous basis, especially among populations and regions of higher risk.

AB - BACKGROUND: Previous data, although scant, indicated that the incidence of HIV in China has increased over the past decade. There is a growing concern about the impact of the HIV epidemic on blood safety. METHODS AND MATERIALS: We used donation data from five geographically-disperse blood centers in 2013-2016 participating in the Recipient Epidemiology and Donor Evaluation Study-III (REDS–III) China program to estimate HIV prevalence and incidence among blood donors. Multivariable logistic regression model was used to examine factors associated with HIV infection in Chinese blood donors. RESULTS: The overall HIV prevalence among first-time donors from 2013 through 2016 was 68.04 per 100,000 donors (95% CI 61.68–74.40). The HIV incidence rate was estimated to be 37.93 per 100,000 person-years (95% CI 30.62–46.97) among first-time donors and 20.55 per 100,000 person-years (95% CI 16.95–24.91) among repeat donors. There was substantial variation in HIV prevalence and incidence rates across blood centers. Multivariable logistic regression results showed that among first-time donors, being male, older than 25 years, minority ethnicity, less than college education, and certain occupations (commercial services, factory workers, retired, unemployed, or self-employed) were associated with positive HIV confirmatory testing results. CONCLUSION: HIV prevalence and incidence among blood donors remain low in the selected five regions in China; however, an increasing trend is observed at some blood centers. It is important to monitor HIV epidemiology in Chinese blood donors on a continuous basis, especially among populations and regions of higher risk.

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