TY - JOUR
T1 - HIV prevalence and incidence estimates among blood donors in five regions in China
AU - for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III)
AU - Shi, Ling
AU - Liu, Yu
AU - Wang, Jingxing
AU - Zeng, Peibin
AU - Gao, Zhan
AU - Wang, Shaoli
AU - Fu, Ping
AU - Liu, Jing
AU - Mao, Wei
AU - He, Weilan
AU - Ma, Hongli
AU - Huang, Mei
AU - Wan, Jianhua
AU - Liao, Dan
AU - Brambilla, Donald
AU - Sullivan, Marian
AU - Zou, Shimian
AU - Ness, Paul
AU - He, Miao
AU - Shan, Hua
N1 - Funding Information:
The authors would like to acknowledge the Recipient Epidemiology and Donor Evaluation - III (REDS-III), International Component (China) program supported by the National Heart Lung and Blood Institute (NHLBI), National Institutes of Health (NIH). The authors want to express our heartfelt gratitude to the staff at all participating blood centers and researchers (Zhiyang Liu, Yang Huang, Ling Ke, Bingting Wu) at Institute of Blood Transfusion in China for their contribution to this project. The authors appreciate enormously the commitment and hard work of the study coordinator, Mr. Wei Cai at Stanford Health Care. The authors thank gratefully the data coordinating center, Research Triangle Institute, Inc. (RTI), especially Ms. Michelle Yuan, for their dedicated work. We also want to thank our in-country central data coordinating center, FEI Systems, especially Dr. Jiao Gu and Mr. Guang Song for their support and outstanding performance. In addition, we greatly appreciate the continuous support and constructive guidance from Dr. Simone Glynn from the NHLBI and the REDS-III Publication Committee, especially Drs. Roger Dodd, Edward Murphy, Steven Kleinman, and Bryan Spencer.
Funding Information:
The authors would like to acknowledge the Recipient Epidemiology and Donor Evaluation ‐ III (REDS‐III), International Component (China) program supported by the National Heart Lung and Blood Institute (NHLBI), National Institutes of Health (NIH). The authors want to express our heartfelt gratitude to the staff at all participating blood centers and researchers (Zhiyang Liu, Yang Huang, Ling Ke, Bingting Wu) at Institute of Blood Transfusion in China for their contribution to this project. The authors appreciate enormously the commitment and hard work of the study coordinator, Mr. Wei Cai at Stanford Health Care. The authors thank gratefully the data coordinating center, Research Triangle Institute, Inc. (RTI), especially Ms. Michelle Yuan, for their dedicated work. We also want to thank our in‐country central data coordinating center, FEI Systems, especially Dr. Jiao Gu and Mr. Guang Song for their support and outstanding performance. In addition, we greatly appreciate the continuous support and constructive guidance from Dr. Simone Glynn from the NHLBI and the REDS‐III Publication Committee, especially Drs. Roger Dodd, Edward Murphy, Steven Kleinman, and Bryan Spencer.
Publisher Copyright:
© 2019 AABB
PY - 2020/1/1
Y1 - 2020/1/1
N2 - BACKGROUND: Previous data, although scant, indicated that the incidence of HIV in China has increased over the past decade. There is a growing concern about the impact of the HIV epidemic on blood safety. METHODS AND MATERIALS: We used donation data from five geographically-disperse blood centers in 2013-2016 participating in the Recipient Epidemiology and Donor Evaluation Study-III (REDS–III) China program to estimate HIV prevalence and incidence among blood donors. Multivariable logistic regression model was used to examine factors associated with HIV infection in Chinese blood donors. RESULTS: The overall HIV prevalence among first-time donors from 2013 through 2016 was 68.04 per 100,000 donors (95% CI 61.68–74.40). The HIV incidence rate was estimated to be 37.93 per 100,000 person-years (95% CI 30.62–46.97) among first-time donors and 20.55 per 100,000 person-years (95% CI 16.95–24.91) among repeat donors. There was substantial variation in HIV prevalence and incidence rates across blood centers. Multivariable logistic regression results showed that among first-time donors, being male, older than 25 years, minority ethnicity, less than college education, and certain occupations (commercial services, factory workers, retired, unemployed, or self-employed) were associated with positive HIV confirmatory testing results. CONCLUSION: HIV prevalence and incidence among blood donors remain low in the selected five regions in China; however, an increasing trend is observed at some blood centers. It is important to monitor HIV epidemiology in Chinese blood donors on a continuous basis, especially among populations and regions of higher risk.
AB - BACKGROUND: Previous data, although scant, indicated that the incidence of HIV in China has increased over the past decade. There is a growing concern about the impact of the HIV epidemic on blood safety. METHODS AND MATERIALS: We used donation data from five geographically-disperse blood centers in 2013-2016 participating in the Recipient Epidemiology and Donor Evaluation Study-III (REDS–III) China program to estimate HIV prevalence and incidence among blood donors. Multivariable logistic regression model was used to examine factors associated with HIV infection in Chinese blood donors. RESULTS: The overall HIV prevalence among first-time donors from 2013 through 2016 was 68.04 per 100,000 donors (95% CI 61.68–74.40). The HIV incidence rate was estimated to be 37.93 per 100,000 person-years (95% CI 30.62–46.97) among first-time donors and 20.55 per 100,000 person-years (95% CI 16.95–24.91) among repeat donors. There was substantial variation in HIV prevalence and incidence rates across blood centers. Multivariable logistic regression results showed that among first-time donors, being male, older than 25 years, minority ethnicity, less than college education, and certain occupations (commercial services, factory workers, retired, unemployed, or self-employed) were associated with positive HIV confirmatory testing results. CONCLUSION: HIV prevalence and incidence among blood donors remain low in the selected five regions in China; however, an increasing trend is observed at some blood centers. It is important to monitor HIV epidemiology in Chinese blood donors on a continuous basis, especially among populations and regions of higher risk.
UR - http://www.scopus.com/inward/record.url?scp=85077023157&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85077023157&partnerID=8YFLogxK
U2 - 10.1111/trf.15636
DO - 10.1111/trf.15636
M3 - Article
C2 - 31845344
AN - SCOPUS:85077023157
SN - 0041-1132
VL - 60
SP - 117
EP - 125
JO - Transfusion
JF - Transfusion
IS - 1
ER -