HIV mono-infection is associated with FIB-4 - A noninvasive index of liver fibrosis - In women

Jason T. Blackard, Jeffrey A. Welge, Lynn E. Taylor, Kenneth H. Mayer, Robert S. Klein, David D. Celentano, Denise J. Jamieson, Lytt Gardner, Kenneth E. Sherman

Research output: Contribution to journalArticlepeer-review

Abstract

Background: FIB-4 represents a noninvasive, composite index that is a validated measure of hepatic fibrosis, which is an important indicator of liver disease. To date, there are limited data regarding hepatic fibrosis in women. Methods: FIB-4 was evaluated in a cohort of 1227 women, and associations were evaluated in univariate and multivariate regression models among 4 groups of subjects classified by their human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection status. Results: The median FIB-4 scores were 0.60 in HIV-/HCV-women, 0.83 in HIV-/HCV+ women, 0.86 in HIV+/HCV-women, and 1.30 in HIV+/HCV+ women. In the HIV/HCV co-infected group, multivariate analysis showed that CD4+ cell count and albumin level were negatively associated with FIB-4 (P <.0001), whereas antiretroviral therapy (ART) was positively associated with FIB-4 score (P =.0008). For the HIV mono-infected group, multivariate analysis showed that CD4+ cell count (P <.0001) and albumin level (P =.0019) were negatively correlated with FIB-4 score, ART was positively associated with FIB-4 score (P =.0008), and plasma HIV RNA level was marginally associated with FIB-4 score (P =.080). In 72 HIV mono-infected women who were also hepatitis B surface antigen negative, ART naive, and reported no recent alcohol intake, plasma HIV RNA level was associated with increased FIB-4 score (P =.030). Conclusions: HIV RNA level was associated with increased FIB-4 score in the absence of hepatitis B, hepatitis C, ART, or alcohol use, suggesting a potential relationship between HIV infection and hepatic fibrosis in vivo. A better understanding of the various demographic and virologic variables that contribute to hepatic fibrosis may lead to more effective treatment of HIV infection and its co-morbid conditions.

Original languageEnglish (US)
Pages (from-to)674-680
Number of pages7
JournalClinical Infectious Diseases
Volume52
Issue number5
DOIs
StatePublished - Mar 1 2011

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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