HIV integration and T cell death: Additional commentary

Arik Cooper, Mayra García, Constantinos Petrovas, Takuya Yamamoto, Richard A. Koup, Gary J. Nabel

Research output: Contribution to journalArticlepeer-review

Abstract

Estaquier et al. provide commentary on our paper that elucidated the mechanism by which HIV-1 causes cell death in activated CD4 T lymphocytes. We showed that proviral DNA integration triggers DNA-PK dependent death signaling, leading to p53 phosphorylation and cell demise (Cooper A et al. Nature 498:376-379, 2013). They have raised several hypothetical points that we further clarify here.

Original languageEnglish (US)
Article number150
JournalRetrovirology
Volume10
Issue number1
DOIs
StatePublished - Dec 9 2013
Externally publishedYes

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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