HIV Infection, Tenofovir Disoproxil Fumarate, and Urine α1-Microglobulin: A Cross-sectional Analysis in the Multicenter AIDS Cohort Study

Vasantha Jotwani, Rebecca Scherzer, Michelle M. Estrella, Lisa Paula Jacobson, Mallory D. Witt, Frank J. Palella, Bernard Macatangay, Michael Bennett, Chirag Parikh, Joachim H. Ix, Michael G. Shlipak

Research output: Contribution to journalArticle

Abstract

Background: Tenofovir disoproxil fumarate (TDF) can cause proximal tubular damage and chronic kidney disease in human immunodeficiency virus (HIV)-infected individuals. Urine α1-microglobulin (A1M), a low-molecular-weight protein indicative of proximal tubular dysfunction, may enable earlier detection of TDF-associated tubular toxicity. Study Design: Cross-sectional. Setting & Participants: 883 HIV-infected and 350 -uninfected men enrolled in the Multicenter AIDS Cohort Study. Predictors: HIV infection and TDF exposure. Outcome: Urine A1M level. Results: Urine A1M was detectable in 737 (83%) HIV-infected and 202 (58%) -uninfected men (P

Original languageEnglish (US)
JournalAmerican Journal of Kidney Diseases
DOIs
StateAccepted/In press - Nov 4 2015

Fingerprint

Tenofovir
Virus Diseases
Acquired Immunodeficiency Syndrome
Cohort Studies
Cross-Sectional Studies
HIV
Urine
Chronic Renal Insufficiency
Molecular Weight

Keywords

  • Antiretroviral (ARV) medication
  • Biomarker
  • HIV infection
  • Kidney damage
  • Multicenter AIDS Cohort Study (MACS)
  • Nephrotoxicity
  • Proximal tubular dysfunction
  • Tenofovir disoproxil fumarate (TDF)
  • Tubular toxicity
  • Urine α-microglobulin (A1M)

ASJC Scopus subject areas

  • Nephrology

Cite this

HIV Infection, Tenofovir Disoproxil Fumarate, and Urine α1-Microglobulin : A Cross-sectional Analysis in the Multicenter AIDS Cohort Study. / Jotwani, Vasantha; Scherzer, Rebecca; Estrella, Michelle M.; Jacobson, Lisa Paula; Witt, Mallory D.; Palella, Frank J.; Macatangay, Bernard; Bennett, Michael; Parikh, Chirag; Ix, Joachim H.; Shlipak, Michael G.

In: American Journal of Kidney Diseases, 04.11.2015.

Research output: Contribution to journalArticle

Jotwani, Vasantha ; Scherzer, Rebecca ; Estrella, Michelle M. ; Jacobson, Lisa Paula ; Witt, Mallory D. ; Palella, Frank J. ; Macatangay, Bernard ; Bennett, Michael ; Parikh, Chirag ; Ix, Joachim H. ; Shlipak, Michael G. / HIV Infection, Tenofovir Disoproxil Fumarate, and Urine α1-Microglobulin : A Cross-sectional Analysis in the Multicenter AIDS Cohort Study. In: American Journal of Kidney Diseases. 2015.
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AU - Jacobson, Lisa Paula

AU - Witt, Mallory D.

AU - Palella, Frank J.

AU - Macatangay, Bernard

AU - Bennett, Michael

AU - Parikh, Chirag

AU - Ix, Joachim H.

AU - Shlipak, Michael G.

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