TY - JOUR
T1 - HIV infection-related tuberculosis
T2 - Clinical manifestations and treatment
AU - Sterling, Timothy R.
AU - Pham, Paul A.
AU - Chaisson, Richard E.
N1 - Funding Information:
Potential conflicts of interest. T.S. has received research grants from Pfizer. P.P. and R.C.: no conflicts.
Funding Information:
Supplement sponsorship. This article is part of a supplement entitled “Synergistic Pandemics: Confronting the Global HIV and Tuberculosis Epidemics,” which was sponsored by the Center for Global Health Policy, a project of the Infectious Diseases Society of America and the HIV Medicine Association, through a grant from the Bill & Melinda Gates Foundation.
PY - 2010/5/15
Y1 - 2010/5/15
N2 - Several aspects of human immunodeficiency virus (HIV) infection-related tuberculosis (TB) and its treatment differ from those of TB in HIV-uninfected persons. The risk of TB and the clinical and radiographic manifestations of disease are primary examples. Antiretroviral therapy has a profound effect on lowering the risk of TB in HIV-infected persons, but it can also be associated with immune reconstitution inflammatory disease and unmasking of previously subclinical disease. There are also differences in treatment of HIV infection-related TB because of overlapping drug toxicities and drug-drug interactions between antiretroviral therapy and anti-TB therapy.
AB - Several aspects of human immunodeficiency virus (HIV) infection-related tuberculosis (TB) and its treatment differ from those of TB in HIV-uninfected persons. The risk of TB and the clinical and radiographic manifestations of disease are primary examples. Antiretroviral therapy has a profound effect on lowering the risk of TB in HIV-infected persons, but it can also be associated with immune reconstitution inflammatory disease and unmasking of previously subclinical disease. There are also differences in treatment of HIV infection-related TB because of overlapping drug toxicities and drug-drug interactions between antiretroviral therapy and anti-TB therapy.
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U2 - 10.1086/651495
DO - 10.1086/651495
M3 - Review article
C2 - 20397952
AN - SCOPUS:77951798462
SN - 1058-4838
VL - 50
SP - S223-S230
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - SUPPL. 3
ER -