HIV Infection Is Independently Associated with Increased CT Scan Lung Density

Research output: Contribution to journalArticle

Abstract

Rationale and Objectives Noninfectious pulmonary complications are common among HIV-infected individuals and may be detected early by quantitative computed tomography (CT) scanning. The association of HIV disease markers with CT lung density measurement remains poorly understood. Materials and Methods One hundred twenty-five participants free of spirometry-defined lung disease were recruited from a longitudinal cohort study of HIV-infected and HIV-uninfected individuals to undergo standardized CT scan of the chest. Parenchymal density for the entire lung volume was calculated using computerized software. Qualitative assessment of CT scans was conducted by two radiologists masked to HIV status. Linear regression models were developed to determine the independent association of markers of HIV infection on inspiratory scan mean lung density (MLD). Results HIV-infected participants had a significantly higher MLD (denser lung) compared to HIV-uninfected participants (−815 Hounsfield unit [HU] vs −837 HU; P = 0.002). After adjusting for relevant covariates, HIV infection was independently associated with 19.9 HU higher MLD (95% CI 6.04 to 33.7 HU; P = 0.005). In qualitative assessment, only ground glass attenuation and cysts were noted more commonly among HIV-infected individuals compared to HIV-uninfected individuals (34% vs 17% [P = 0.045] and 27% vs 10% [P = 0.03], respectively). No qualitative radiographic abnormalities attenuated the association between HIV infection and increased MLD. Conclusions HIV infection is independently associated with increased lung density. Although qualitative CT abnormalities were common in this cohort, only ground glass attenuation and cysts were noted more frequently in HIV-infected participants, suggesting that the increased lung density observed among HIV-infected individuals may be associated with subclinical inflammatory lung changes.

Original languageEnglish (US)
Pages (from-to)137-145
Number of pages9
JournalAcademic Radiology
Volume24
Issue number2
DOIs
StatePublished - Feb 1 2017

Fingerprint

HIV Infections
Tomography
HIV
Lung
Glass
Cysts
Linear Models
Spirometry
Lung Diseases
Longitudinal Studies
Cohort Studies
Thorax
Software

Keywords

  • HIV
  • lung function
  • respiratory tract disease
  • spirometry
  • tomography, x-ray computed

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

HIV Infection Is Independently Associated with Increased CT Scan Lung Density. / Drummond, M. Bradley; Lambert, Allison A.; Hussien, Amira; Lin, Cheng; Merlo, Christian; Wise, Robert A; Kirk, Gregory D; Brown, Robert Howard.

In: Academic Radiology, Vol. 24, No. 2, 01.02.2017, p. 137-145.

Research output: Contribution to journalArticle

@article{7c1f0d6f6e2642e2ad6e3c9611995be1,
title = "HIV Infection Is Independently Associated with Increased CT Scan Lung Density",
abstract = "Rationale and Objectives Noninfectious pulmonary complications are common among HIV-infected individuals and may be detected early by quantitative computed tomography (CT) scanning. The association of HIV disease markers with CT lung density measurement remains poorly understood. Materials and Methods One hundred twenty-five participants free of spirometry-defined lung disease were recruited from a longitudinal cohort study of HIV-infected and HIV-uninfected individuals to undergo standardized CT scan of the chest. Parenchymal density for the entire lung volume was calculated using computerized software. Qualitative assessment of CT scans was conducted by two radiologists masked to HIV status. Linear regression models were developed to determine the independent association of markers of HIV infection on inspiratory scan mean lung density (MLD). Results HIV-infected participants had a significantly higher MLD (denser lung) compared to HIV-uninfected participants (−815 Hounsfield unit [HU] vs −837 HU; P = 0.002). After adjusting for relevant covariates, HIV infection was independently associated with 19.9 HU higher MLD (95{\%} CI 6.04 to 33.7 HU; P = 0.005). In qualitative assessment, only ground glass attenuation and cysts were noted more commonly among HIV-infected individuals compared to HIV-uninfected individuals (34{\%} vs 17{\%} [P = 0.045] and 27{\%} vs 10{\%} [P = 0.03], respectively). No qualitative radiographic abnormalities attenuated the association between HIV infection and increased MLD. Conclusions HIV infection is independently associated with increased lung density. Although qualitative CT abnormalities were common in this cohort, only ground glass attenuation and cysts were noted more frequently in HIV-infected participants, suggesting that the increased lung density observed among HIV-infected individuals may be associated with subclinical inflammatory lung changes.",
keywords = "HIV, lung function, respiratory tract disease, spirometry, tomography, x-ray computed",
author = "Drummond, {M. Bradley} and Lambert, {Allison A.} and Amira Hussien and Cheng Lin and Christian Merlo and Wise, {Robert A} and Kirk, {Gregory D} and Brown, {Robert Howard}",
year = "2017",
month = "2",
day = "1",
doi = "10.1016/j.acra.2016.09.019",
language = "English (US)",
volume = "24",
pages = "137--145",
journal = "Academic Radiology",
issn = "1076-6332",
publisher = "Elsevier USA",
number = "2",

}

TY - JOUR

T1 - HIV Infection Is Independently Associated with Increased CT Scan Lung Density

AU - Drummond, M. Bradley

AU - Lambert, Allison A.

AU - Hussien, Amira

AU - Lin, Cheng

AU - Merlo, Christian

AU - Wise, Robert A

AU - Kirk, Gregory D

AU - Brown, Robert Howard

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Rationale and Objectives Noninfectious pulmonary complications are common among HIV-infected individuals and may be detected early by quantitative computed tomography (CT) scanning. The association of HIV disease markers with CT lung density measurement remains poorly understood. Materials and Methods One hundred twenty-five participants free of spirometry-defined lung disease were recruited from a longitudinal cohort study of HIV-infected and HIV-uninfected individuals to undergo standardized CT scan of the chest. Parenchymal density for the entire lung volume was calculated using computerized software. Qualitative assessment of CT scans was conducted by two radiologists masked to HIV status. Linear regression models were developed to determine the independent association of markers of HIV infection on inspiratory scan mean lung density (MLD). Results HIV-infected participants had a significantly higher MLD (denser lung) compared to HIV-uninfected participants (−815 Hounsfield unit [HU] vs −837 HU; P = 0.002). After adjusting for relevant covariates, HIV infection was independently associated with 19.9 HU higher MLD (95% CI 6.04 to 33.7 HU; P = 0.005). In qualitative assessment, only ground glass attenuation and cysts were noted more commonly among HIV-infected individuals compared to HIV-uninfected individuals (34% vs 17% [P = 0.045] and 27% vs 10% [P = 0.03], respectively). No qualitative radiographic abnormalities attenuated the association between HIV infection and increased MLD. Conclusions HIV infection is independently associated with increased lung density. Although qualitative CT abnormalities were common in this cohort, only ground glass attenuation and cysts were noted more frequently in HIV-infected participants, suggesting that the increased lung density observed among HIV-infected individuals may be associated with subclinical inflammatory lung changes.

AB - Rationale and Objectives Noninfectious pulmonary complications are common among HIV-infected individuals and may be detected early by quantitative computed tomography (CT) scanning. The association of HIV disease markers with CT lung density measurement remains poorly understood. Materials and Methods One hundred twenty-five participants free of spirometry-defined lung disease were recruited from a longitudinal cohort study of HIV-infected and HIV-uninfected individuals to undergo standardized CT scan of the chest. Parenchymal density for the entire lung volume was calculated using computerized software. Qualitative assessment of CT scans was conducted by two radiologists masked to HIV status. Linear regression models were developed to determine the independent association of markers of HIV infection on inspiratory scan mean lung density (MLD). Results HIV-infected participants had a significantly higher MLD (denser lung) compared to HIV-uninfected participants (−815 Hounsfield unit [HU] vs −837 HU; P = 0.002). After adjusting for relevant covariates, HIV infection was independently associated with 19.9 HU higher MLD (95% CI 6.04 to 33.7 HU; P = 0.005). In qualitative assessment, only ground glass attenuation and cysts were noted more commonly among HIV-infected individuals compared to HIV-uninfected individuals (34% vs 17% [P = 0.045] and 27% vs 10% [P = 0.03], respectively). No qualitative radiographic abnormalities attenuated the association between HIV infection and increased MLD. Conclusions HIV infection is independently associated with increased lung density. Although qualitative CT abnormalities were common in this cohort, only ground glass attenuation and cysts were noted more frequently in HIV-infected participants, suggesting that the increased lung density observed among HIV-infected individuals may be associated with subclinical inflammatory lung changes.

KW - HIV

KW - lung function

KW - respiratory tract disease

KW - spirometry

KW - tomography, x-ray computed

UR - http://www.scopus.com/inward/record.url?scp=85006930195&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006930195&partnerID=8YFLogxK

U2 - 10.1016/j.acra.2016.09.019

DO - 10.1016/j.acra.2016.09.019

M3 - Article

VL - 24

SP - 137

EP - 145

JO - Academic Radiology

JF - Academic Radiology

SN - 1076-6332

IS - 2

ER -