HIV infection is associated with increased risk for acute exacerbation of COPD

Allison A. Lambert, Gregory D Kirk, Jacquie Astemborski, Shruti Hemendra Mehta, Robert A Wise, M. Bradley Drummond

Research output: Contribution to journalArticle

Abstract

Background: Poorly controlled HIV infection is associated with increased risk for chronic obstructive pulmonary disease (COPD). Acute exacerbations of COPD (AECOPD) are major contributors to morbidity and mortality. Little is known about the association between HIV infection and AECOPD. Methods: We identified 167 individuals with spirometry-confirmed COPD from a longitudinal study of current or former injection drug users at risk or with HIV infection. AECOPD, defined as self-report of worsening breathing requiring treatment with antibiotics or steroids, was assessed at 6-month study visits. Multivariable logistic regression identified factors associated with AECOPD. Results: Of 167 participants, the mean age was 52 years; 89% were black, 30% female, and 32% HIV infected (median CD4 count: 312 cells per milliliter, 46% with detectable HIV RNA). After adjusting for age, gender, smoking history, comorbidity treatment, and airflow obstruction severity, HIV was independently associated with a 2.47 increased odds of AECOPD [95% confidence interval (CI): 1.22 to 5.00]. Compared with HIV-uninfected persons, HIV-infected persons with undetectable (

Original languageEnglish (US)
Pages (from-to)68-74
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Volume69
Issue number1
DOIs
StatePublished - May 1 2015

Fingerprint

Chronic Obstructive Pulmonary Disease
HIV Infections
HIV
Spirometry
CD4 Lymphocyte Count
Drug Users
Self Report
Longitudinal Studies
Comorbidity
Respiration
Logistic Models
Smoking
History
Steroids
RNA
Confidence Intervals
Anti-Bacterial Agents
Morbidity
Injections
Mortality

Keywords

  • airflow limitation
  • chronic obstructive
  • COPD exacerbation
  • HIV
  • pulmonary disease

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

HIV infection is associated with increased risk for acute exacerbation of COPD. / Lambert, Allison A.; Kirk, Gregory D; Astemborski, Jacquie; Mehta, Shruti Hemendra; Wise, Robert A; Drummond, M. Bradley.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 69, No. 1, 01.05.2015, p. 68-74.

Research output: Contribution to journalArticle

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