HIV infection and the PNS

Kevin Tan, Avindra Nath, Ahmet Hoke

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Peripheral nervous system involvement is one of the most common neurological complications of HIV infection. Although type of peripheral nervous system involvement varies depending on the stage of infection, most prevalent type of involvement is HIV-associated distal sensory polyneuropathy. Mechanisms of HIV-associated peripheral neuropathies are unknown. HIV is neuroinvasive and neurovirulent, but not necessarily neurotrophic, suggesting that most of the neurotoxicity of HIV infection is indirect and most likely mediated via chemokines, cytokines, or viral proteins released by the infiltrating macrophages. Furthermore, treatment with antiretroviral drugs contributes to neurotoxicity and development of peripheral neuropathies, sometimes clinically indistinguishable from HIV-induced peripheral neuropathy. Mechanism of antiretroviral toxic neuropathy is likely to be mediated by mitochondrial toxicity leading to distal axonal degeneration. Currently, treatment of HIV-associated peripheral neuropathies is directed at symptom control and strict control of the underlying HIV infection without the use of most toxic antiretroviral drugs.

Original languageEnglish (US)
Title of host publicationChemokine Receptors and NeuroAIDS
Subtitle of host publicationBeyond Co-Receptor Function and Links to Other Neuropathologies
PublisherSpringer New York
Pages51-85
Number of pages35
ISBN (Electronic)9781441907936
ISBN (Print)9781441907929
DOIs
StatePublished - Jan 1 2010

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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