HIV infection and cocaine use induce endothelial damage and dysfunction in African Americans

Research output: Contribution to journalArticle

Abstract

Background: Clinical and epidemiological evidence suggests that HIV infection and cocaine use are associated with an increased risk of premature atherosclerosis. The underlying mechanisms linking HIV infection and cocaine use with early atherosclerosis remain elusive. Methods and results: Endothelin-1 (ET-1) levels in 360 African American participants in Baltimore, Maryland were measured. Quantile regression analysis was performed to examine the associations between ET-1, HIV infection, cocaine use, and other relevant clinical factors. The median of ET-1 in plasma, (1.05 pg/mL with interquartile range: 0.73, 1.40) for those with HIV infection was significantly higher than values for those without HIV infection (0.74 pg/mL with interquartile range: 0.61, 0.93). The median of ET-1 was markedly higher in chronic cocaine users (0.96 pg/mL with interquartile range: 0.71, 1.36) than that in non-cocaine users (0.72 pg/mL with interquartile range: 0.58, 1.06). Multivariate quantile regression suggested that HIV infection and duration of cocaine use were independently associated with plasma ET-1 levels after controlling for potential confounding factors. Conclusions: This study may provide insight into the mechanism of premature atherosclerosis in HIV-infected cocaine users and suggest that measurement of ET-1 in plasma can be used as a marker of early atherosclerosis in HIV infected patients and cocaine users.

Original languageEnglish (US)
Pages (from-to)83-87
Number of pages5
JournalInternational Journal of Cardiology
Volume161
Issue number2
DOIs
StatePublished - Nov 15 2012

Fingerprint

Cocaine
African Americans
Endothelin-1
HIV Infections
Atherosclerosis
HIV
Baltimore
Regression Analysis

Keywords

  • African Americans
  • Cocaine use
  • Endothelin-1
  • HIV infection

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

HIV infection and cocaine use induce endothelial damage and dysfunction in African Americans. / Tai, Hong; Lai, Hong Chen; Jani, Jayesh; Lai, Shenghan; Kickler, Thomas Stephen.

In: International Journal of Cardiology, Vol. 161, No. 2, 15.11.2012, p. 83-87.

Research output: Contribution to journalArticle

@article{534bc93a347e452ebaa972d222311945,
title = "HIV infection and cocaine use induce endothelial damage and dysfunction in African Americans",
abstract = "Background: Clinical and epidemiological evidence suggests that HIV infection and cocaine use are associated with an increased risk of premature atherosclerosis. The underlying mechanisms linking HIV infection and cocaine use with early atherosclerosis remain elusive. Methods and results: Endothelin-1 (ET-1) levels in 360 African American participants in Baltimore, Maryland were measured. Quantile regression analysis was performed to examine the associations between ET-1, HIV infection, cocaine use, and other relevant clinical factors. The median of ET-1 in plasma, (1.05 pg/mL with interquartile range: 0.73, 1.40) for those with HIV infection was significantly higher than values for those without HIV infection (0.74 pg/mL with interquartile range: 0.61, 0.93). The median of ET-1 was markedly higher in chronic cocaine users (0.96 pg/mL with interquartile range: 0.71, 1.36) than that in non-cocaine users (0.72 pg/mL with interquartile range: 0.58, 1.06). Multivariate quantile regression suggested that HIV infection and duration of cocaine use were independently associated with plasma ET-1 levels after controlling for potential confounding factors. Conclusions: This study may provide insight into the mechanism of premature atherosclerosis in HIV-infected cocaine users and suggest that measurement of ET-1 in plasma can be used as a marker of early atherosclerosis in HIV infected patients and cocaine users.",
keywords = "African Americans, Cocaine use, Endothelin-1, HIV infection",
author = "Hong Tai and Lai, {Hong Chen} and Jayesh Jani and Shenghan Lai and Kickler, {Thomas Stephen}",
year = "2012",
month = "11",
day = "15",
doi = "10.1016/j.ijcard.2011.04.034",
language = "English (US)",
volume = "161",
pages = "83--87",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - HIV infection and cocaine use induce endothelial damage and dysfunction in African Americans

AU - Tai, Hong

AU - Lai, Hong Chen

AU - Jani, Jayesh

AU - Lai, Shenghan

AU - Kickler, Thomas Stephen

PY - 2012/11/15

Y1 - 2012/11/15

N2 - Background: Clinical and epidemiological evidence suggests that HIV infection and cocaine use are associated with an increased risk of premature atherosclerosis. The underlying mechanisms linking HIV infection and cocaine use with early atherosclerosis remain elusive. Methods and results: Endothelin-1 (ET-1) levels in 360 African American participants in Baltimore, Maryland were measured. Quantile regression analysis was performed to examine the associations between ET-1, HIV infection, cocaine use, and other relevant clinical factors. The median of ET-1 in plasma, (1.05 pg/mL with interquartile range: 0.73, 1.40) for those with HIV infection was significantly higher than values for those without HIV infection (0.74 pg/mL with interquartile range: 0.61, 0.93). The median of ET-1 was markedly higher in chronic cocaine users (0.96 pg/mL with interquartile range: 0.71, 1.36) than that in non-cocaine users (0.72 pg/mL with interquartile range: 0.58, 1.06). Multivariate quantile regression suggested that HIV infection and duration of cocaine use were independently associated with plasma ET-1 levels after controlling for potential confounding factors. Conclusions: This study may provide insight into the mechanism of premature atherosclerosis in HIV-infected cocaine users and suggest that measurement of ET-1 in plasma can be used as a marker of early atherosclerosis in HIV infected patients and cocaine users.

AB - Background: Clinical and epidemiological evidence suggests that HIV infection and cocaine use are associated with an increased risk of premature atherosclerosis. The underlying mechanisms linking HIV infection and cocaine use with early atherosclerosis remain elusive. Methods and results: Endothelin-1 (ET-1) levels in 360 African American participants in Baltimore, Maryland were measured. Quantile regression analysis was performed to examine the associations between ET-1, HIV infection, cocaine use, and other relevant clinical factors. The median of ET-1 in plasma, (1.05 pg/mL with interquartile range: 0.73, 1.40) for those with HIV infection was significantly higher than values for those without HIV infection (0.74 pg/mL with interquartile range: 0.61, 0.93). The median of ET-1 was markedly higher in chronic cocaine users (0.96 pg/mL with interquartile range: 0.71, 1.36) than that in non-cocaine users (0.72 pg/mL with interquartile range: 0.58, 1.06). Multivariate quantile regression suggested that HIV infection and duration of cocaine use were independently associated with plasma ET-1 levels after controlling for potential confounding factors. Conclusions: This study may provide insight into the mechanism of premature atherosclerosis in HIV-infected cocaine users and suggest that measurement of ET-1 in plasma can be used as a marker of early atherosclerosis in HIV infected patients and cocaine users.

KW - African Americans

KW - Cocaine use

KW - Endothelin-1

KW - HIV infection

UR - http://www.scopus.com/inward/record.url?scp=84868690405&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868690405&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2011.04.034

DO - 10.1016/j.ijcard.2011.04.034

M3 - Article

VL - 161

SP - 83

EP - 87

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 2

ER -