HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D

Meredith S. Shiels; Gregory D Kirk; M. Bradley Drummond; Dilsher Dhillon; Samir M. Hanash; Ayumu Taguchi; Eric A. Engels

doi:10.1093/infdis/jix510

HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D

Meredith S. Shiels, Gregory D Kirk, M. Bradley Drummond, Dilsher Dhillon, Samir M. Hanash, Ayumu Taguchi, Eric A. Engels

Bloomberg School of Public Health

Research output: Contribution to journal › Article

Abstract

Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher HIV RNA (P trend = .05), and without highly active antiretroviral therapy (P = .03). These associations were not observed for SFTPD. Serum levels of pro-SFTPB are elevated among PWH and are associated with immunosuppression and uncontrolled viremia.

Original language	English (US)
Pages (from-to)	413-417
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	217
Issue number	3
DOIs	https://doi.org/10.1093/infdis/jix510
State	Published - Jan 17 2018

Keywords

HIV
inflammation
lung
surfactant protein

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

Access to Document

10.1093/infdis/jix510

Fingerprint Dive into the research topics of 'HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D'. Together they form a unique fingerprint.

Cite this

Shiels, M. S., Kirk, G. D., Drummond, M. B., Dhillon, D., Hanash, S. M., Taguchi, A., & Engels, E. A. (2018). HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D. Journal of Infectious Diseases, 217(3), 413-417. https://doi.org/10.1093/infdis/jix510

@article{14025319f2644e5696be4c8c000a52e1,

title = "HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D",

abstract = "Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher HIV RNA (P trend = .05), and without highly active antiretroviral therapy (P = .03). These associations were not observed for SFTPD. Serum levels of pro-SFTPB are elevated among PWH and are associated with immunosuppression and uncontrolled viremia.",

keywords = "HIV, inflammation, lung, surfactant protein",

author = "Shiels, {Meredith S.} and Kirk, {Gregory D} and Drummond, {M. Bradley} and Dilsher Dhillon and Hanash, {Samir M.} and Ayumu Taguchi and Engels, {Eric A.}",

year = "2018",

month = jan,

day = "17",

doi = "10.1093/infdis/jix510",

language = "English (US)",

volume = "217",

pages = "413--417",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D

AU - Shiels, Meredith S.

AU - Kirk, Gregory D

AU - Drummond, M. Bradley

AU - Dhillon, Dilsher

AU - Hanash, Samir M.

AU - Taguchi, Ayumu

AU - Engels, Eric A.

PY - 2018/1/17

Y1 - 2018/1/17

N2 - Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher HIV RNA (P trend = .05), and without highly active antiretroviral therapy (P = .03). These associations were not observed for SFTPD. Serum levels of pro-SFTPB are elevated among PWH and are associated with immunosuppression and uncontrolled viremia.

AB - Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher HIV RNA (P trend = .05), and without highly active antiretroviral therapy (P = .03). These associations were not observed for SFTPD. Serum levels of pro-SFTPB are elevated among PWH and are associated with immunosuppression and uncontrolled viremia.

KW - HIV

KW - inflammation

KW - lung

KW - surfactant protein

UR - http://www.scopus.com/inward/record.url?scp=85041220765&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041220765&partnerID=8YFLogxK

U2 - 10.1093/infdis/jix510

DO - 10.1093/infdis/jix510

M3 - Article

C2 - 29272472

AN - SCOPUS:85041220765

VL - 217

SP - 413

EP - 417

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 3

ER -