HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D

Meredith S. Shiels, Gregory D. Kirk, M. Bradley Drummond, Dilsher Dhillon, Samir M. Hanash, Ayumu Taguchi, Eric A. Engels

Research output: Contribution to journalArticlepeer-review

Abstract

Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher HIV RNA (P trend = .05), and without highly active antiretroviral therapy (P = .03). These associations were not observed for SFTPD. Serum levels of pro-SFTPB are elevated among PWH and are associated with immunosuppression and uncontrolled viremia.

Original languageEnglish (US)
Pages (from-to)413-417
Number of pages5
JournalJournal of Infectious Diseases
Volume217
Issue number3
DOIs
StatePublished - Jan 17 2018

Keywords

  • HIV
  • inflammation
  • lung
  • surfactant protein

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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