HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D

Meredith S. Shiels; Gregory D. Kirk; M. Bradley Drummond; Dilsher Dhillon; Samir M. Hanash; Ayumu Taguchi; Eric A. Engels

doi:10.1093/infdis/jix510

HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D

Meredith S. Shiels, Gregory D. Kirk, M. Bradley Drummond, Dilsher Dhillon, Samir M. Hanash, Ayumu Taguchi, Eric A. Engels

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher HIV RNA (P trend = .05), and without highly active antiretroviral therapy (P = .03). These associations were not observed for SFTPD. Serum levels of pro-SFTPB are elevated among PWH and are associated with immunosuppression and uncontrolled viremia.

Original language	English (US)
Pages (from-to)	413-417
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	217
Issue number	3
DOIs	https://doi.org/10.1093/infdis/jix510
State	Published - Jan 17 2018

Keywords

HIV
inflammation
lung
surfactant protein

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1093/infdis/jix510

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title = "HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D",

abstract = "Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher HIV RNA (P trend = .05), and without highly active antiretroviral therapy (P = .03). These associations were not observed for SFTPD. Serum levels of pro-SFTPB are elevated among PWH and are associated with immunosuppression and uncontrolled viremia.",

keywords = "HIV, inflammation, lung, surfactant protein",

author = "Shiels, {Meredith S.} and Kirk, {Gregory D.} and Drummond, {M. Bradley} and Dilsher Dhillon and Hanash, {Samir M.} and Ayumu Taguchi and Engels, {Eric A.}",

note = "Funding Information: Financial support. This work was supported by National Institutes of Health grants R01HL126549, U01HL121814, U01DA036297, and K23HL103192; The Canary Foundation, MD Anderson Cancer Center; the University of Texas MD Anderson Cancer Center Moon Shots Program; and by the Intramural Research Program of the National Cancer Institute. Publisher Copyright: {\textcopyright} 2017 The Author(s). Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

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AU - Hanash, Samir M.

AU - Taguchi, Ayumu

AU - Engels, Eric A.

N1 - Funding Information: Financial support. This work was supported by National Institutes of Health grants R01HL126549, U01HL121814, U01DA036297, and K23HL103192; The Canary Foundation, MD Anderson Cancer Center; the University of Texas MD Anderson Cancer Center Moon Shots Program; and by the Intramural Research Program of the National Cancer Institute. Publisher Copyright: © 2017 The Author(s). Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2018/1/17

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N2 - Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher HIV RNA (P trend = .05), and without highly active antiretroviral therapy (P = .03). These associations were not observed for SFTPD. Serum levels of pro-SFTPB are elevated among PWH and are associated with immunosuppression and uncontrolled viremia.

AB - Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher HIV RNA (P trend = .05), and without highly active antiretroviral therapy (P = .03). These associations were not observed for SFTPD. Serum levels of pro-SFTPB are elevated among PWH and are associated with immunosuppression and uncontrolled viremia.

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HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D

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Keywords

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