HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D

Meredith S. Shiels, Gregory D Kirk, M. Bradley Drummond, Dilsher Dhillon, Samir M. Hanash, Ayumu Taguchi, Eric A. Engels

Research output: Contribution to journalArticle

Abstract

Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher HIV RNA (P trend = .05), and without highly active antiretroviral therapy (P = .03). These associations were not observed for SFTPD. Serum levels of pro-SFTPB are elevated among PWH and are associated with immunosuppression and uncontrolled viremia.

Original languageEnglish (US)
Pages (from-to)413-417
Number of pages5
JournalJournal of Infectious Diseases
Volume217
Issue number3
DOIs
StatePublished - Jan 17 2018

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Pulmonary Surfactant-Associated Protein D
Virus Diseases
HIV
Viremia
Highly Active Antiretroviral Therapy
CD4 Lymphocyte Count
Drug Users
Immunosuppression
Pneumonia
Smoking
IgA receptor
RNA
Injections
Serum

Keywords

  • HIV
  • inflammation
  • lung
  • surfactant protein

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Shiels, M. S., Kirk, G. D., Drummond, M. B., Dhillon, D., Hanash, S. M., Taguchi, A., & Engels, E. A. (2018). HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D. Journal of Infectious Diseases, 217(3), 413-417. https://doi.org/10.1093/infdis/jix510

HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D. / Shiels, Meredith S.; Kirk, Gregory D; Drummond, M. Bradley; Dhillon, Dilsher; Hanash, Samir M.; Taguchi, Ayumu; Engels, Eric A.

In: Journal of Infectious Diseases, Vol. 217, No. 3, 17.01.2018, p. 413-417.

Research output: Contribution to journalArticle

Shiels, MS, Kirk, GD, Drummond, MB, Dhillon, D, Hanash, SM, Taguchi, A & Engels, EA 2018, 'HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D', Journal of Infectious Diseases, vol. 217, no. 3, pp. 413-417. https://doi.org/10.1093/infdis/jix510
Shiels, Meredith S. ; Kirk, Gregory D ; Drummond, M. Bradley ; Dhillon, Dilsher ; Hanash, Samir M. ; Taguchi, Ayumu ; Engels, Eric A. / HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D. In: Journal of Infectious Diseases. 2018 ; Vol. 217, No. 3. pp. 413-417.
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