Abstract
Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher HIV RNA (P trend = .05), and without highly active antiretroviral therapy (P = .03). These associations were not observed for SFTPD. Serum levels of pro-SFTPB are elevated among PWH and are associated with immunosuppression and uncontrolled viremia.
Original language | English (US) |
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Pages (from-to) | 413-417 |
Number of pages | 5 |
Journal | Journal of Infectious Diseases |
Volume | 217 |
Issue number | 3 |
DOIs | |
State | Published - Jan 17 2018 |
Keywords
- HIV
- inflammation
- lung
- surfactant protein
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases