Abstract
Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher HIV RNA (P trend = .05), and without highly active antiretroviral therapy (P = .03). These associations were not observed for SFTPD. Serum levels of pro-SFTPB are elevated among PWH and are associated with immunosuppression and uncontrolled viremia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 413-417 |
| Number of pages | 5 |
| Journal | Journal of Infectious Diseases |
| Volume | 217 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 17 2018 |
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Keywords
- HIV
- inflammation
- lung
- surfactant protein
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases
Cite this
HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D. / Shiels, Meredith S.; Kirk, Gregory D; Drummond, M. Bradley; Dhillon, Dilsher; Hanash, Samir M.; Taguchi, Ayumu; Engels, Eric A.
In: Journal of Infectious Diseases, Vol. 217, No. 3, 17.01.2018, p. 413-417.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D
AU - Shiels, Meredith S.
AU - Kirk, Gregory D
AU - Drummond, M. Bradley
AU - Dhillon, Dilsher
AU - Hanash, Samir M.
AU - Taguchi, Ayumu
AU - Engels, Eric A.
PY - 2018/1/17
Y1 - 2018/1/17
N2 - Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher HIV RNA (P trend = .05), and without highly active antiretroviral therapy (P = .03). These associations were not observed for SFTPD. Serum levels of pro-SFTPB are elevated among PWH and are associated with immunosuppression and uncontrolled viremia.
AB - Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher HIV RNA (P trend = .05), and without highly active antiretroviral therapy (P = .03). These associations were not observed for SFTPD. Serum levels of pro-SFTPB are elevated among PWH and are associated with immunosuppression and uncontrolled viremia.
KW - HIV
KW - inflammation
KW - lung
KW - surfactant protein
UR - http://www.scopus.com/inward/record.url?scp=85041220765&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041220765&partnerID=8YFLogxK
U2 - 10.1093/infdis/jix510
DO - 10.1093/infdis/jix510
M3 - Article
C2 - 29272472
AN - SCOPUS:85041220765
VL - 217
SP - 413
EP - 417
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 3
ER -