HIV incidence among post-partum women in Zimbabwe: Risk factors and the effect of vitamin A supplementation

Jean H. Humphrey, John W. Hargrove, Lucie C. Malaba, Peter J. Iliff, Lawrence H. Moulton, Kuda Mutasa, Partson Zvandasara, Kusum J. Nathoo, Faith Mzengeza, Henry Chidawanyika, Lynn S. Zijenah, Brian J. Ward

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: To test whether post-partum vitamin A supplementation can reduce incident HIV among post-partum women and identify risk factors for HIV incidence. DESIGN: Randomized, placebo-controlled trial METHODS: Between November 1997 and January 2001, 14 110 women were randomly administered 400 000 IU vitamin A or placebo within 96 h post-partum. HIV incidence was monitored among 9562 HIV-negative women. RESULTS: Cumulative incidence was 3.4% [95% confidence interval (CI), 3.0-3.8] and 6.5% (95% CI, 5.7-7.4) over 12 and 24 months post-partum, respectively. Vitamin A supplementation had no impact on incidence [hazard ratio (HR), 1.08; 95% CI, 0.85-1.38]. However, among 398 women for whom baseline serum retinol was measured, those with levels indicative of deficiency (< 0.7 μmol/l, 9.2% of those measured) were 10.4 (95% CI, 3.0-36.3) times more likely to seroconvert than women with higher concentrations. Furthermore, among women with low serum retinol, vitamin A supplementation tended to be protective against incidence (HR, 0.29; 95% CI, 0.03-2.60; P = 0.26), although not significantly so, perhaps due to limited statistical power. Severe anaemia (haemoglobin < 70 g/l) was associated with a 2.7-fold (95%CI, 1.2-6.1) greater incidence. Younger women were at higher risk of HIV infection: incidence declined by 5.7% (2.8-8.6) with each additional year of age. CONCLUSION: Among post-partum women, a single large-dose vitamin A supplementation had no effect on incidence, although low serum retinol was a risk factor for seroconversion. Further investigation is required to determine whether vitamin A supplementation of vitamin-A-deficient women or treatment of anaemic women can reduce HIV incidence.

Original languageEnglish (US)
Pages (from-to)1437-1446
Number of pages10
Issue number10
StatePublished - Jun 2006


  • Anaemia
  • HIV incidence
  • Vitamin A deficiency
  • Vitamin A supplementation
  • Women
  • Zimbabwe

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


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