TY - JOUR
T1 - HIV-I reverse transcriptase variation in plasma and genital secretion of antiretroviral-naive females
AU - Shanmugasundaram, Uma
AU - Solomon, Suniti
AU - Shanmugam, Saravanan
AU - Murugavel, Kailapuri G.
AU - Nagalingeswaran, Kumarasamy
AU - Solomon, Sunil S.
AU - Mayer, Kenneth H.
AU - Pachamuthu, Balakrishnan
PY - 2009/11
Y1 - 2009/11
N2 - The reverse transcriptase (RT) enzyme of HIV type 1 (HIV-1) is largely targeted by the host immune selection pressure and would differ in the anatomical compartments, thereby having a drastic impact on viral quasi-species evolution. The HIV-1 RT region sequenced from plasma and genital secretions of 8 antiretroviral treatment (ART)-naive females was analyzed for the pattern of amino acid mutations and the ratio of synonymous and nonsynonymous substitutions to determine whether it is under different selection pressure in both the compartments. Phylogenetic and mutational analysis of the HIV-1 RT in plasma and genital secretions of HIV-1-infected ART-naive females showed limited variation likely reflecting the absence of differential selection pressure and therefore genetic variation in these compartments.
AB - The reverse transcriptase (RT) enzyme of HIV type 1 (HIV-1) is largely targeted by the host immune selection pressure and would differ in the anatomical compartments, thereby having a drastic impact on viral quasi-species evolution. The HIV-1 RT region sequenced from plasma and genital secretions of 8 antiretroviral treatment (ART)-naive females was analyzed for the pattern of amino acid mutations and the ratio of synonymous and nonsynonymous substitutions to determine whether it is under different selection pressure in both the compartments. Phylogenetic and mutational analysis of the HIV-1 RT in plasma and genital secretions of HIV-1-infected ART-naive females showed limited variation likely reflecting the absence of differential selection pressure and therefore genetic variation in these compartments.
KW - HIV compartmentalization
KW - HIV-1 reverse transcriptase
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U2 - 10.1177/1545109709347374
DO - 10.1177/1545109709347374
M3 - Article
C2 - 19822735
AN - SCOPUS:77951216710
SN - 1545-1097
VL - 8
SP - 375
EP - 378
JO - Journal of the International Association of Physicians in AIDS Care
JF - Journal of the International Association of Physicians in AIDS Care
IS - 6
ER -