HIV, HCV, and HBV co-infections in a rural area of Shanxi Province with a history of commercial blood donation

Ruiling Dong, Xiaochun Qiao, Wangqian Jia, Michelle Wong, Hanzhu Qian, Xiwen Zheng, Wenge Xing, Shenghan Lai, Zhenglai Wu, Yan Jiang, Ning Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Unhygienic blood collection in the early 1990s led to blood-borne infections in Central China. This study aimed to estimate human immunodeficiency virus (HIV) co-infection with hepatitis C and B viruses (HCV and HBV) and their risk factors in a rural area of Shanxi Province with a history of commercial blood donation. Methods: A cross-sectional study was conducted in 2004. All adult residents in the target area were invited to participate in the study. Face-to-face interviews were completed and blood specimens were tested for HIV, HCV, and HBV surface antigen (HBsAg). Results: Prevalence rates of HIV, HCV, and HBsAg were 1.3% (40/3 062), 12.7% (389/3 062), and 3.5% (103/2982), respectively. Of the 40 HIV-positive specimens, 85% were HCV positive and 2.5% were HBsAg positive. The history of commercial blood donation was positively associated with HIV, HCV, and HIV/HCV co-infections, but was negatively associated with HBsAg seropositivity. Migration for employment in the last 5 years was positively related to HIV, HBsAg, and HIV/HCV co-infections. Univariate logistic analysis showed that illegal drug use, number of sex partners, extramarital sex behavior, commercial sex behavior, and condom use rate were not related to anti-HIV, anti-HCV, HBsAg seropositivity or their co-infections. Conclusion: The history of commercial blood donation was the main risk factor for HIV, HCV, and HIV/HCV co-infections in this former commercial blood donation area. HIV and HCV prevention and treatment interventions are important in this area.

Original languageEnglish (US)
Pages (from-to)207-213
Number of pages7
JournalBiomedical and Environmental Sciences
Volume24
Issue number3
DOIs
StatePublished - Jun 2011

Keywords

  • Co-infections
  • Commercial Blood Donation
  • Hepatitis B Virus Surface Antigen
  • Hepatitis C Virus
  • Human immunodeficiency Virus

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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