HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations

Chava B. Pocernich, Rukhsana Sultana, Hafiz Mohmmad-Abdul, Avindra Nath, D. Allan Butterfield

Research output: Contribution to journalReview article

Abstract

Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly and indirectly. The role of Tat in HIV-dementia and possible therapeutic strategies involving endogenous and exogenous antioxidants are discussed.

Original languageEnglish (US)
Pages (from-to)14-26
Number of pages13
JournalBrain Research Reviews
Volume50
Issue number1
DOIs
StatePublished - Dec 1 2005

Keywords

  • Antioxidant
  • HIV-dementia
  • Oxidative stress
  • Tat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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    Pocernich, C. B., Sultana, R., Mohmmad-Abdul, H., Nath, A., & Butterfield, D. A. (2005). HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations. Brain Research Reviews, 50(1), 14-26. https://doi.org/10.1016/j.brainresrev.2005.04.002