HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations

Chava B. Pocernich; Rukhsana Sultana; Hafiz Mohmmad-Abdul; Avindra Nath; D. Allan Butterfield

doi:10.1016/j.brainresrev.2005.04.002

HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations

Chava B. Pocernich, Rukhsana Sultana, Hafiz Mohmmad-Abdul, Avindra Nath, D. Allan Butterfield

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly and indirectly. The role of Tat in HIV-dementia and possible therapeutic strategies involving endogenous and exogenous antioxidants are discussed.

Original language	English (US)
Pages (from-to)	14-26
Number of pages	13
Journal	Brain Research Reviews
Volume	50
Issue number	1
DOIs	https://doi.org/10.1016/j.brainresrev.2005.04.002
State	Published - Dec 1 2005

Keywords

Antioxidant
HIV-dementia
Oxidative stress
Tat

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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10.1016/j.brainresrev.2005.04.002

Cite this

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title = "HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations",

abstract = "Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly and indirectly. The role of Tat in HIV-dementia and possible therapeutic strategies involving endogenous and exogenous antioxidants are discussed.",

keywords = "Antioxidant, HIV-dementia, Oxidative stress, Tat",

author = "Pocernich, {Chava B.} and Rukhsana Sultana and Hafiz Mohmmad-Abdul and Avindra Nath and Butterfield, {D. Allan}",

note = "Funding Information: This work was supported in part by grants from NIH (MH64409; AG-10836; AG-05119) to D.A.B. and (RO1 NS39253; P20 RR15592) to A.N. ",

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AU - Pocernich, Chava B.

AU - Sultana, Rukhsana

AU - Mohmmad-Abdul, Hafiz

AU - Nath, Avindra

AU - Butterfield, D. Allan

N1 - Funding Information: This work was supported in part by grants from NIH (MH64409; AG-10836; AG-05119) to D.A.B. and (RO1 NS39253; P20 RR15592) to A.N.

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly and indirectly. The role of Tat in HIV-dementia and possible therapeutic strategies involving endogenous and exogenous antioxidants are discussed.

AB - Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly and indirectly. The role of Tat in HIV-dementia and possible therapeutic strategies involving endogenous and exogenous antioxidants are discussed.

KW - Antioxidant

KW - HIV-dementia

KW - Oxidative stress

KW - Tat

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HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations

Abstract

Keywords

ASJC Scopus subject areas

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