Abstract
Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly and indirectly. The role of Tat in HIV-dementia and possible therapeutic strategies involving endogenous and exogenous antioxidants are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 14-26 |
| Number of pages | 13 |
| Journal | Brain Research Reviews |
| Volume | 50 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 1 2005 |
Keywords
- Antioxidant
- HIV-dementia
- Oxidative stress
- Tat
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
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Pocernich, C. B., Sultana, R., Mohmmad-Abdul, H., Nath, A., & Butterfield, D. A. (2005). HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations. Brain Research Reviews, 50(1), 14-26. https://doi.org/10.1016/j.brainresrev.2005.04.002