HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations

Chava B. Pocernich; Rukhsana Sultana; Hafiz Mohmmad-Abdul; Avindra Nath; D. Allan Butterfield

doi:10.1016/j.brainresrev.2005.04.002

HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations

Chava B. Pocernich, Rukhsana Sultana, Hafiz Mohmmad-Abdul, Avindra Nath, D. Allan Butterfield

School of Medicine

Research output: Contribution to journal › Article

Abstract

Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly and indirectly. The role of Tat in HIV-dementia and possible therapeutic strategies involving endogenous and exogenous antioxidants are discussed.

Original language	English (US)
Pages (from-to)	14-26
Number of pages	13
Journal	Brain Research Reviews
Volume	50
Issue number	1
DOIs	https://doi.org/10.1016/j.brainresrev.2005.04.002
Publication status	Published - Dec 1 2005

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Keywords

Antioxidant
HIV-dementia
Oxidative stress
Tat

ASJC Scopus subject areas

Neuroscience(all)

Cite this

Pocernich, C. B., Sultana, R., Mohmmad-Abdul, H., Nath, A., & Butterfield, D. A. (2005). HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations. Brain Research Reviews, 50(1), 14-26. https://doi.org/10.1016/j.brainresrev.2005.04.002

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Access to Document

10.1016/j.brainresrev.2005.04.002