Abstract
Survival in people infected with HIV has improved because of an increasingly powerful array of antiretroviral treatments, but neurological symptoms due to comorbid conditions, including infection with hepatitis C virus, malnutrition, and the effects of accelerated cardiovascular disease and ageing, are increasingly salient. A therapeutic gap seems to exist between the salutary effects of antiretroviral regimens and the normalisation of neurological function in HIV-associated neurocognitive disorders. Despite the advances in antiretroviral therapy, CNS opportunistic infections remain a serious burden worldwide. Most opportunistic infections can be recognised by a combination of characteristic clinical and radiological features and are treatable, but some important challenges remain in the diagnosis and management of HIV-associated opportunistic infections.
Original language | English (US) |
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Pages (from-to) | 605-617 |
Number of pages | 13 |
Journal | The Lancet Neurology |
Volume | 11 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2012 |
ASJC Scopus subject areas
- Clinical Neurology