HIV-associated opportunistic infections of the CNS

Ik Lin Tan, Bryan R. Smith, Gloria von Geldern, Farrah J. Mateen, Justin C. McArthur

Research output: Contribution to journalReview articlepeer-review


Survival in people infected with HIV has improved because of an increasingly powerful array of antiretroviral treatments, but neurological symptoms due to comorbid conditions, including infection with hepatitis C virus, malnutrition, and the effects of accelerated cardiovascular disease and ageing, are increasingly salient. A therapeutic gap seems to exist between the salutary effects of antiretroviral regimens and the normalisation of neurological function in HIV-associated neurocognitive disorders. Despite the advances in antiretroviral therapy, CNS opportunistic infections remain a serious burden worldwide. Most opportunistic infections can be recognised by a combination of characteristic clinical and radiological features and are treatable, but some important challenges remain in the diagnosis and management of HIV-associated opportunistic infections.

Original languageEnglish (US)
Pages (from-to)605-617
Number of pages13
JournalThe Lancet Neurology
Issue number7
StatePublished - Jul 2012

ASJC Scopus subject areas

  • Clinical Neurology


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