Abstract
Survival in people infected with HIV has improved because of an increasingly powerful array of antiretroviral treatments, but neurological symptoms due to comorbid conditions, including infection with hepatitis C virus, malnutrition, and the effects of accelerated cardiovascular disease and ageing, are increasingly salient. A therapeutic gap seems to exist between the salutary effects of antiretroviral regimens and the normalisation of neurological function in HIV-associated neurocognitive disorders. Despite the advances in antiretroviral therapy, CNS opportunistic infections remain a serious burden worldwide. Most opportunistic infections can be recognised by a combination of characteristic clinical and radiological features and are treatable, but some important challenges remain in the diagnosis and management of HIV-associated opportunistic infections.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 605-617 |
| Number of pages | 13 |
| Journal | The Lancet Neurology |
| Volume | 11 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2012 |
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ASJC Scopus subject areas
- Clinical Neurology
Cite this
HIV-associated opportunistic infections of the CNS. / Tan, Ik Lin; Smith, Bryan R.; von Geldern, Gloria; Mateen, Farrah J.; McArthur, Justin Charles.
In: The Lancet Neurology, Vol. 11, No. 7, 07.2012, p. 605-617.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HIV-associated opportunistic infections of the CNS
AU - Tan, Ik Lin
AU - Smith, Bryan R.
AU - von Geldern, Gloria
AU - Mateen, Farrah J.
AU - McArthur, Justin Charles
PY - 2012/7
Y1 - 2012/7
N2 - Survival in people infected with HIV has improved because of an increasingly powerful array of antiretroviral treatments, but neurological symptoms due to comorbid conditions, including infection with hepatitis C virus, malnutrition, and the effects of accelerated cardiovascular disease and ageing, are increasingly salient. A therapeutic gap seems to exist between the salutary effects of antiretroviral regimens and the normalisation of neurological function in HIV-associated neurocognitive disorders. Despite the advances in antiretroviral therapy, CNS opportunistic infections remain a serious burden worldwide. Most opportunistic infections can be recognised by a combination of characteristic clinical and radiological features and are treatable, but some important challenges remain in the diagnosis and management of HIV-associated opportunistic infections.
AB - Survival in people infected with HIV has improved because of an increasingly powerful array of antiretroviral treatments, but neurological symptoms due to comorbid conditions, including infection with hepatitis C virus, malnutrition, and the effects of accelerated cardiovascular disease and ageing, are increasingly salient. A therapeutic gap seems to exist between the salutary effects of antiretroviral regimens and the normalisation of neurological function in HIV-associated neurocognitive disorders. Despite the advances in antiretroviral therapy, CNS opportunistic infections remain a serious burden worldwide. Most opportunistic infections can be recognised by a combination of characteristic clinical and radiological features and are treatable, but some important challenges remain in the diagnosis and management of HIV-associated opportunistic infections.
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UR - http://www.scopus.com/inward/citedby.url?scp=84862336697&partnerID=8YFLogxK
U2 - 10.1016/S1474-4422(12)70098-4
DO - 10.1016/S1474-4422(12)70098-4
M3 - Article
C2 - 22710754
AN - SCOPUS:84862336697
VL - 11
SP - 605
EP - 617
JO - The Lancet Neurology
JF - The Lancet Neurology
SN - 1474-4422
IS - 7
ER -