HIV-associated opportunistic infections of the CNS

Ik Lin Tan, Bryan R. Smith, Gloria von Geldern, Farrah J. Mateen, Justin Charles McArthur

Research output: Contribution to journalArticle

Abstract

Survival in people infected with HIV has improved because of an increasingly powerful array of antiretroviral treatments, but neurological symptoms due to comorbid conditions, including infection with hepatitis C virus, malnutrition, and the effects of accelerated cardiovascular disease and ageing, are increasingly salient. A therapeutic gap seems to exist between the salutary effects of antiretroviral regimens and the normalisation of neurological function in HIV-associated neurocognitive disorders. Despite the advances in antiretroviral therapy, CNS opportunistic infections remain a serious burden worldwide. Most opportunistic infections can be recognised by a combination of characteristic clinical and radiological features and are treatable, but some important challenges remain in the diagnosis and management of HIV-associated opportunistic infections.

Original languageEnglish (US)
Pages (from-to)605-617
Number of pages13
JournalThe Lancet Neurology
Volume11
Issue number7
DOIs
StatePublished - Jul 2012

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Opportunistic Infections
HIV
Malnutrition
Hepacivirus
Cardiovascular Diseases
Therapeutics
Infection

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

HIV-associated opportunistic infections of the CNS. / Tan, Ik Lin; Smith, Bryan R.; von Geldern, Gloria; Mateen, Farrah J.; McArthur, Justin Charles.

In: The Lancet Neurology, Vol. 11, No. 7, 07.2012, p. 605-617.

Research output: Contribution to journalArticle

Tan, IL, Smith, BR, von Geldern, G, Mateen, FJ & McArthur, JC 2012, 'HIV-associated opportunistic infections of the CNS', The Lancet Neurology, vol. 11, no. 7, pp. 605-617. https://doi.org/10.1016/S1474-4422(12)70098-4
Tan, Ik Lin ; Smith, Bryan R. ; von Geldern, Gloria ; Mateen, Farrah J. ; McArthur, Justin Charles. / HIV-associated opportunistic infections of the CNS. In: The Lancet Neurology. 2012 ; Vol. 11, No. 7. pp. 605-617.
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