TY - JOUR
T1 - HIV and Stem Cell Transplantation
AU - Echenique, Ignacio A.
AU - Nelson, George E.
AU - Stosor, Valentina
AU - Durand, Christine M.
N1 - Funding Information:
Conflict of Interest Christine Durand, Ignacio Echenique, and George Nelson declare no conflicts of interest. Valentina Stosor has received a grant from NIH/NIAID.
Publisher Copyright:
© 2014, Springer Science+Business Media New York.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - In human immunodeficiency virus (HIV)-infected persons, the incidence of hematologic malignancies, including leukemia and lymphoma, is increased despite the use of successful antiretroviral therapy. Hematopoietic stem cell transplantation (SCT) is emerging as a safe and effective therapy for HIV-infected persons with hematologic malignancies. Management of these patients is complicated by drug–drug interactions involving antiretroviral therapy (ART) that may impact conditioning agent efficacy and metabolism of immunosuppressive medications and potentiate drug toxicities. As such, optimal strategies for ART remain controversial. We discuss recent advances, controversies, and future directions related to SCT in HIV-infected persons, including the investigation of allogeneic SCT as a strategy for HIV cure.
AB - In human immunodeficiency virus (HIV)-infected persons, the incidence of hematologic malignancies, including leukemia and lymphoma, is increased despite the use of successful antiretroviral therapy. Hematopoietic stem cell transplantation (SCT) is emerging as a safe and effective therapy for HIV-infected persons with hematologic malignancies. Management of these patients is complicated by drug–drug interactions involving antiretroviral therapy (ART) that may impact conditioning agent efficacy and metabolism of immunosuppressive medications and potentiate drug toxicities. As such, optimal strategies for ART remain controversial. We discuss recent advances, controversies, and future directions related to SCT in HIV-infected persons, including the investigation of allogeneic SCT as a strategy for HIV cure.
KW - AIDS
KW - Allogeneic stem cell transplantation
KW - Antiretroviral therapy
KW - Autologous stem cell transplantation
KW - Bone marrow transplantation
KW - GVHD
KW - HIV
KW - HIV cure
KW - HIV eradication
KW - HIV reservoir
KW - Hodgkin lymphoma
KW - Non-Hodgkin lymphoma
KW - Stem cell transplantation
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U2 - 10.1007/s11908-014-0424-y
DO - 10.1007/s11908-014-0424-y
M3 - Review article
C2 - 25120135
AN - SCOPUS:84957435249
SN - 1523-3847
VL - 16
SP - 1
EP - 10
JO - Current Infectious Disease Reports
JF - Current Infectious Disease Reports
IS - 9
M1 - 424
ER -