HIV and SIV associated thrombocytopenia: An expanding role for platelets in the pathogenesis of HIV

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Abstract

Thrombocytopenia is common in HIV and SIV infection, and is often associated with disease progression. HIV and SIV-associated thrombocytopenia arise through multiple mechanisms, including decreased platelet production, increased platelet destruction due to HIV-mimetic anti-platelet antibodies, and increased use of activated platelets. Activated platelets have the potential to contribute to the pathogenesis of HIV and SIV by interacting directly with inflammatory cells and endothelium and by releasing soluble immunomodulatory cytokines.

Original languageEnglish (US)
Pages (from-to)e25-e32
JournalDrug Discovery Today: Disease Mechanisms
Volume8
Issue number1-2
DOIs
StatePublished - Jun 1 2011

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ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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